Insect antimicrobial peptides: potential tools for the prevention of skin cancer

Tonk, Miray; Vilcinskas, Andreas; Rahnamaeian, Mohammad

doi:10.1007/s00253-016-7718-y

Cited by 61 publications

(41 citation statements)

References 100 publications

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“…We recently isolated a 15-mer peptide from the American cockroach, showed that it has antimicrobial activity, and designated it Periplanetasin-2 (Peri-2, YPCKLNLKLGKVPFH). Based on previous findings that antimicrobial peptides exhibit various biological effects against mammalian cells [23], we herein assessed whether Peri-2 could inhibit the epithelial damage and inflammation induced by C. difficile toxin A. Our results revealed that Peri-2 can inhibit toxin A-induced cellular toxicity in HT29 cells and ameliorate toxin A-induced enteritis in mice.…”

Section: Introductionmentioning

confidence: 94%

The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut

Hong¹,

Zhang²,

Yoon³

et al. 2017

Journal of Microbiology and Biotechnology

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, which causes pseudomembranous colitis, releases toxin A and toxin B. These toxins are considered to be the main causative agents for the disease pathogenesis, and their expression is associated with a marked increase of apoptosis in mucosal epithelial cells. Colonic epithelial cells are believed to form a physical barrier between the lumen and the submucosa, and abnormally increased mucosal epithelial cell apoptosis is considered to be an initial step in gut inflammation responses. Therefore, one approach to treating pseudomembranous colitis would be to develop agents that block the mucosal epithelial cell apoptosis caused by toxin A, thus restoring barrier function and curing inflammatory responses in the gut. We recently isolated an antimicrobial peptide, Periplanetasin-2 (Peri-2, YPCKLNLKLGKVPFH) from the American cockroach, whose extracts have shown great potential for clinical use. Here, we assessed whether Peri-2 could inhibit the cell toxicity and inflammation caused by toxin A. Indeed, in human colonocyte HT29 cells, Peri-2 inhibited the toxin A-induced decrease in cell proliferation and ameliorated the cell apoptosis induced by this toxin. Moreover, in the toxin A-induced mouse enteritis model, Peri-2 blocked the mucosal disruption and inflammatory response caused by toxin A. These results suggest that the American cockroach peptide Peri-2 could be a possible drug candidate for addressing the pseudomembranous colitis caused by toxin A.

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Section: Introductionmentioning

confidence: 94%

The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut

Hong¹,

Zhang²,

Yoon³

et al. 2017

Journal of Microbiology and Biotechnology

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“…Skin cancer is a widespread cancer, as skin serves as the first line of defence against heat, sunlight, injury, and infection [121]. Several in vivo studies have revealed that pomegranate possess anti-skin tumor promoting properties in various animal models [122,123].…”

Section: Pomegranate and Skin Cancermentioning

confidence: 99%

Possible use of Punica granatum (Pomegranate) in cancer therapy

Khwairakpam

Bordoloi

Thakur

et al. 2018

Pharmacological Research

131

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The intake of fruits has proven to reduce the risk and incidence of cancer worldwide and plays a crucial role in cancer prevention. Pomegranate (Punica granatum), which belongs to the Punicaceae family, is one such plant that contains beneficial nutrients as well as many bioactive components and important phytochemicals that can be attributed to cancer-related therapeutic purposes. Pomegranate possesses antioxidant, anti-inflammatory, anti-proliferative, anti-angiogenic, anti-invasive, and anti-metastatic properties, and induces apoptosis. It also down-regulates various signaling pathways such as NF-κB, PI3K/AKT/mTOR, and Wnt, and down-regulates the expression of genes that are responsible in cancer development, such as anti-apoptotic genes, MMPs, VEGF, c-met, cyclins, Cdks, and pro-inflammatory cytokines. Therefore, inclusion of the fruit in one's diet would assist in a healthy life protected from cancer and also act as an effective chemotherapeutic with no toxic side effects.

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“…Система врожденного иммунитета животных обеспечивает немедленную защиту организма в ответ на внедрение патогена благодаря большому числу молекулярных факторов, реализующих рекогносцировочные и эффекторные механизмы ее функционирования. Наряду с множеством белковых факторов врожденного иммунитета, таких как компоненты системы комплемента, лизоцим, лактоферрин, цитокины и др., особую роль в защите организма от инфекций играют эндогенные антимикробные пептиды, продуцируемые позвоночными [28] и беспозвоночными [23] животными, растениями [72], грибами и бактерия ми. В отличие от многих классических антибиотиков, являющихся продуктами вторичного метаболизма, подавляющее большинство АМП синтезируются непосредственно на рибосомах.…”

Section: общая характеристика свойства и структура ампunclassified

Antimicrobial Peptides — A Potential Replacement for Traditional Antibiotics

Мусин

2018

Russian Journal of Infection and Immunity

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Antimicrobial peptides are a heterogeneous group of molecules involved in the innate and acquired immune response of various organisms, ranging from prokaryotes to mammals, including humans. They consist of 12–50 amino acid residues; have different physico-chemical and biological properties. The most common feature is their ability to destroy the prokaryotic cell membrane, which causes cell death. In the action, the molecules of antimicrobial peptides are embedded in the target bacteriological cells and change their conformation, forming structures in some cases resembling channels. Some other molecules of antimicrobial peptides can cover the surface of a bacteriological cell and form a carpet, when they reach a critical mass they act like detergents. In addition, being positively charged molecules of such peptides, penetrating through the membranes of parasitic and bacteriological cells, bind to polyanionic RNA and DNA molecules. Among the benefits of antimicrobial peptides is their high metabolic activity, low probability of occurrence of addictions and side effects. In addition, bacteriological pathogens that previously did not have resistance to any antimicrobial peptide are difficult to develop a strategy to control them. In this connection, these peptides are the most promising moleculessubstitutes for traditional antibiotics. The article discusses the approaches and strategies of therapeutic use, the studies of antimicrobial peptides identified in recent years; The most frequently encountered mechanisms of interaction of antimicrobial peptides and a bacteriological membrane are described, the physicochemical properties of peptide molecules are described; the results of studies on the detection of resistance of some strains of bacteria to antimicrobial peptides and antibiotics in general are summarized.

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Insect antimicrobial peptides: potential tools for the prevention of skin cancer

Cited by 61 publications

References 100 publications

The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut

The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut

Possible use of Punica granatum (Pomegranate) in cancer therapy

Antimicrobial Peptides — A Potential Replacement for Traditional Antibiotics

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