Insect growth regulators as potential insecticides to control olive fruit fly (<i>Bactrocera oleae</i> Rossi): insect toxicity bioassays and molecular docking approach

Bengochea, Paloma; Christiaens, Olivier; Amor, F.; Viñuela, Elisa; Rougé, Pierre; Medina, Pilar; Smagghe, Guy

doi:10.1002/ps.3350

Cited by 8 publications

(7 citation statements)

References 40 publications

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“…Additionally, as shown in Figure 5, because the larvae consumed many compound-treated leaves during the first 2 days, they showed various symptoms of toxicity in the subsequent growth and developmental stages, such as blackened and unmolted bodies, malformed pupae, and deformed moths (panels A−C of Figure 5). The above phenomena were similar to those previous reports, 29,30 and the findings indicated that these N-benzoylthioureas of osthole probably interfere with the synthesis of the growth hormone of M. separata, causing abnormalities at three growth stages and eventually leading to the death of M. separata. Aphicidal Activity of Osthole-Derived N-Benzoylthioureas against M. persicae.…”

Section: Data Forsupporting

confidence: 91%

Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates

Yang

Liu

Han

et al. 2022

J. Agric. Food Chem.

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To discover novel natural-product-based insecticide candidates, herein, a variety of osthole-derived Nbenzoylthioureas were synthesized and assessed for their insecticidal activities against three insect pests. An insecticidal assay showed that most of the target osthole-derived N-benzoylthioureas displayed a more potent and broad-spectrum insecticidal effect than the parent osthole after the introduction of N-benzoylthioureas on the C-3′ position of osthole. Compound B24 displayed the most potent growth inhibitory (GI) effect on Mythimna separata Walker, with a final corrected mortality rate of 82.1% when treated with a concentration of 1 mg/mL, which was 1.64-and 1.53-fold higher in comparison to osthole and the botanical insecticide toosendanin, respectively. Compounds B22, B23, and B25 displayed a more promising aphicidal effect on Myzus persicae Sulzer, and their LD 50 values were 0.015, 0.017, and 0.019 μg/larvae, respectively, superior to the commercially available insecticide rotenone (0.024 μg/larvae). Derivatives B19, B20, B23, and B25 displayed more potent larvicidal activity against Plutella xylostella Linnaeus, with LC 50 values of 0.22, 0.26, 0.15, and 0.30 mg/mL, respectively, exceeding that of rotenone (0.37 mg/mL). Furthermore, both compounds B19 and B23 against P. xylostella were found to be more effective than rotenone in a control efficacy assay under greenhouse conditions. The structure−activity relationship (SAR) suggested that osthole-derived N-benzoylthioureas are more active in most cases when the R group is an electron-withdrawing group than when it is an electron-donating group, especially for halogenated groups. Additionally, the potent compounds B19 and B23 possessed good selectivity and were less toxic to non-target organisms. This study suggests that these osthole-derived N-benzoylthioureas could be further studied in depth as eco-friendly natural product pesticides in crop protection.

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Section: Data Forsupporting

confidence: 91%

Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates

Yang

Liu

Han

et al. 2022

J. Agric. Food Chem.

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“…Specifically, knock downs of AChE and EcR interfered with whitefly mating and oviposition before it resulted in mortality. The latter genes also are targets of insecticides such as Imidacloprid46 and benzoyl hydrazine4748 that affect the neuronal and steroid functions of insects. Previously RNAi technology has been shown effective in down-regulating expression of midgut-expressed osmoregulatory genes, aquaporin and alpha glucosidase of whitefly32, for which greater than 70% mortality was shown, six days post-feeding on transgenic tobacco plants, compared to negative controls.…”

Section: Discussionmentioning

confidence: 99%

RNAi-mediated mortality of the whitefly through transgenic expression of double-stranded RNA homologous to acetylcholinesterase and ecdysone receptor in tobacco plants

Malik

Raza

Amin

et al. 2016

Sci Rep

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The whitefly Bemisia tabaci (Genn.) is a pest and vector of plant viruses to crop and ornamental plants worldwide. Using RNA interference (RNAi) to down regulate whitefly genes by expressing their homologous double stranded RNAs in plants has great potential for management of whiteflies to reduce plant virus disease spread. Using a Tobacco rattle virus-derived plasmid for in planta transient expression of double stranded RNA (dsRNA) homologous to the acetylcholinesterase (AChE) and ecdysone receptor (EcR) genes of B. tabaci, resulted in significant adult whitefly mortality. Nicotiana tabacum L. plants expressing dsRNA homologous to B. tabaci AChE and EcR were constructed by fusing sequences derived from both genes. Mortality of adult whiteflies exposed to dsRNA by feeding on N. tabacum plants, compared to non-dsRNA expressing plants, recorded at 24-hr intervals post-ingestion for three days, was >90% and 10%, respectively. Analysis of gene expression by real time quantitative PCR indicated that whitefly mortality was attributable to the down-regulation of both target genes by RNAi. Results indicated that knock down of whitefly genes involved in neuronal transmission and transcriptional activation of developmental genes, has potential as a bio-pesticide to reduce whitefly population size and thereby decrease virus spread.

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“…Control methods are based on the use of (a) insecticide treatments (bait applications (insecticides mixed with an attractant) and cover sprays); and (b) traps [20]. Organochlorides, organophosphates and carbamates were the first insecticides used against the olive fruit fly, followed by the introduction of pyrethroids, neonicotinoids, and spinosad as bait treatment, which is recognized to be an integral component of IPM as it reduces pesticide levels and environmental impact on natural enemies and pollinators [21][22][23][24][25]. Kaolin works as a physical barrier that prevents egg laying in the olive fruit [26].…”

Section: Bactrocera Oleae-psyttalia Concolor: Compatibility Between Cmentioning

confidence: 99%

Side Effects of Pesticides on the Olive Fruit Fly Parasitoid Psyttalia concolor (Szépligeti): A Review

et al. 2020

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Pesticide applications in olive orchards could alter the biological control of parasitoid Psyttalia concolor Szépligeti (Hymenoptera: Braconidae) on the key pest Bactrocera oleae Rossi (Diptera: Tephritidae). Psyttalia concolor adults can be contaminated by exposure to spray droplets, contact with treated surfaces or oral uptake from contaminated food sources. Pesticides impact both pest and parasitoid populations when they coexist in time and space, as they reduce pest numbers available for parasitoids and might cause toxic effects to parasitoids from which they need to recover. Therefore, the appropriate timing and application of selective chemical treatments provides the opportunity to incorporate this parasitoid in the IPM of B. oleae. This manuscript reviews the current literature on lethal and sublethal effects of insecticides, fungicides, herbicides, and biopesticides on P. concolor. Insecticides were generally more toxic, particularly organophosphates and pyrethroids, while herbicides and biopesticides had less effects on mortality and reproductive parameters. Some fungicides were quite harmful. Most of the studies were conducted in laboratory conditions, focused on reproduction as the only sublethal effect, exclusively considered the effect of a single pesticide and persistence was hardly explored. Field studies, currently quite scarce, are absolutely needed to satisfactorily assess the impact of pesticides on P. concolor.

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Insect growth regulators as potential insecticides to control olive fruit fly (Bactrocera oleae Rossi): insect toxicity bioassays and molecular docking approach

Abstract: IGR molecules similar to the RH-5849 molecule, and different from methoxyfenozide and tebufenozide, might have potential in controlling this pest.

Cited by 8 publications

References 40 publications

Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates

Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates

RNAi-mediated mortality of the whitefly through transgenic expression of double-stranded RNA homologous to acetylcholinesterase and ecdysone receptor in tobacco plants

Side Effects of Pesticides on the Olive Fruit Fly Parasitoid Psyttalia concolor (Szépligeti): A Review

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