Insect-Repellent Properties of 2-Ethylhexanediol-1,3

Granett, Philip; Haynes, Harry L.

doi:10.1093/jee/38.6.671

Cited by 9 publications

(3 citation statements)

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“…56 Phenol was produced by all human subjects in the study of Curran et al 72 In addition to amides like deet, aliphatic alcohols have been popular historically as insect repellents, e.g., the series of decanol (C 10 ) through tetradecanol (C 14 ), 103 and Rutgers 612. 104,105 Dogan and Rossignol examined various fragrances and compositions that contained alcohols such as geraniol and dimethyl cyclormol (hexahydrodimethyl methanoinden-5-ol) and found these to either inhibit or repel mosquitoes in am odified Feinsod-Spielman olfactometer. 24 In contrast to the well known attractant 1-octen-3-ol, 106,107 several related, more volatile unsaturated alcohols, including linalool will inhibit attraction by Aedes aegypti in laboratory bioassays.…”

Section: Attraction-inhibition By Alcoholsmentioning

confidence: 99%

Human Emanations and Related Natural Compounds That Inhibit Mosquito Host-Finding Abilities

Bernier¹,

Kline

Posey³

2006

Insect Repellents

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Section: Attraction-inhibition By Alcoholsmentioning

confidence: 99%

Human Emanations and Related Natural Compounds That Inhibit Mosquito Host-Finding Abilities

Bernier¹,

Kline

Posey³

2006

Insect Repellents

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“…Traditional repellents such as oil of citronella and various formulations of pyrethrum were tested but found to be inadequate 42. Much work and progress in the identification and evaluation of efficacious compounds and mixtures were reported by Granett and Haynes at Rutgers University,49 the Naval Medical Research Institute, Bethesda, MD, and largely the Orlando, FL, USDA Laboratory, Bureau of Entomology and Plant Quarantine, FL, from 1942 to 1947,50 which was supported by the USDA Office of Scientific Research and Development and the US Army 51. The large‐scale screening effort evaluated approximately 6000 chemicals37, 50–52 against several dipteran species (the yellow‐fever mosquito, Aedes aegypti L., a malaria mosquito, Anopheles quadrimaculatus Say, and the stable fly, Stomoxys calcitrans L.) and found only a small percentage to equal that of existing standards.…”

Section: Structural Diversity Of Chemical Repellentsmentioning

confidence: 99%

“…2). In particular, ethylhexanediol was a very effective repellent against mosquitoes developed by Granett and Haynes49 as part of a screening initiated in 1935. Some amino analogs of ethylhexanediol were synthesized and evaluated against Ae.…”

Section: Structural Diversity Of Chemical Repellentsmentioning

confidence: 99%

Mosquito repellents: a review of chemical structure diversity and olfaction

2010

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Research on mosquito chemical repellents continues to advance, along with knowledge of mosquito olfaction and behavior, mosquito-host interactions and chemical structure. New tools and technologies have revealed information about insect olfactory mechanisms and processing, providing a more complex approach for the interpretation of how chemical repellents influence host-seeking and feeding behavior. Even with these advances, there is still a large amount of information contained in the early works on insect repellents. Many of the standard test methods and chemicals that are still used for evaluating active repellents were developed in the 1940s. These studies contain valuable references to the activity of different structural classes of chemicals, and serve as a guide to optimization of select compounds for insect repellency effects.

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Effective Insect Repellent Formulation in both Surfactantless and Classical Microemulsions with a Long‐Lasting Protection for Human Beings

Drapeau

Verdier²,

Touraud

et al. 2009

Chemistry & Biodiversity

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The aim of this work is to develop a new generation of repellent products with a long-lasting protection based on a natural component, para-menthane-3,8-diol (PMD). The active is first rendered soluble in a surfactantless microemulsion (H(2)O/(i)PrOH/PMD) and then in classical microemulsions. The presence of self-associated nanostructures is detected by dynamic light scattering (DLS). A synergetic system of surfactants (Cremophor) RH40 and Texapon N70) is used. Additionally, 2-ethylhexane-1,3-diol and ethyl (-)-(S)-lactate are incorporated. The final product contains, as main components, 46% of H(2)O, 25% of (i)PrOH, 20% of non-H(2)O-soluble PMD, and only 4% of surfactants. Investigations of lasting protection on human volunteers are carried out using a cage test bioassay protocol and Aedes aegypti mosquitoes. A complete protection of 315 min is found on the test persons using the surfactantless microemulsion. An extension is observed with the final formulation to reach a mean of complete protection of 385 min. This study demonstrates that alternative formulations using a natural active instead of synthetic chemicals like N,N-diethyl-m-methylbenzamide (DEET) can be efficient for human protection against mosquitoes.

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Insect-Repellent Properties of 2-Ethylhexanediol-1,3

Cited by 9 publications

References 0 publications

Human Emanations and Related Natural Compounds That Inhibit Mosquito Host-Finding Abilities

Human Emanations and Related Natural Compounds That Inhibit Mosquito Host-Finding Abilities

Mosquito repellents: a review of chemical structure diversity and olfaction

Effective Insect Repellent Formulation in both Surfactantless and Classical Microemulsions with a Long‐Lasting Protection for Human Beings

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