Inserting Needles Into the Body: A Meta-Analysis of Brain Activity Associated With Acupuncture Needle Stimulation

Chae, Younbyoung; Chang, D-S; Lee, Soon Ho; Jung, Won Jai; Lee, In Seon; Jackson, Stephen R.; Kong, Jian; Lee, Hyangsook; Park, Hi-Joon; Lee, Hyejung; Wallraven, Christian

doi:10.1016/j.jpain.2012.11.011

Cited by 175 publications

(144 citation statements)

References 63 publications

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“…These findings are consistent with those of previous studies which found that acupuncture stimulation leads to common brain activations in the sensorimotor cortical network, including the insula and SII [7]. Although acupuncture stimulation was only applied to the incorporated rubber hand in the present study, the stimulation clearly produced similar brain activations as does acupuncture to the real hand [7,8]. It is thought that the activations of the DLPFC, insula, and SII were associated with the physiological responses evoked by acupuncture stimulation to the incorporated hand, but only when the participants perceived the rubber hand to be their own.…”

Section: Discussionsupporting

confidence: 93%

“…Neuroimaging studies investigating the acupuncture process have observed overlapping brain activations in the cortical sensorimotor and salient networks, as well as deactivations in the limbic-paralimbic neocortical network [7,13]. From a neurological point of view, the sensations induced by acupuncture are not only the product of the bottom-up modulation of simple needling at somatosensory receptors, but also of the reciprocal interaction of top-down modulation from the brain, such as the incorporation of focused attention and accentuated bodily awareness [21].…”

Section: Introductionmentioning

confidence: 99%

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Psychophysical and neurophysiological responses to acupuncture stimulation to incorporated rubber hand

Chae

Lee

Jung

et al. 2015

Neuroscience Letters

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Psychophysical and neurophysiological responses to acupuncture stimulation to incorporated rubber hand

Chae

Lee

Jung

et al. 2015

Neuroscience Letters

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“…The PCC has been previously linked with selfexperienced pain perception. Although some have reported pain-related deactivation of this region (Chae et al, 2013;Loggia et al, 2012), others have demonstrated pain-induced activity in the PCC (Bromm, 2001;Freund et al, 2010;Nielsen, Balslev, & Hansen, 2005) which has been attributed by some to the emotional-aversive aspect of the painful experiences (Bromm, 2001). Recently, reduced alpha activity was found in the PCC in response to observed painful as compared to nonpainful stimuli (Höfle et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Prior exposure to extreme pain alters neural response to pain in others

Eidelman-Rothman

Goldstein

Weisman

et al. 2016

Cogn Affect Behav Neurosci

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In the extant literature examining the brain mechanisms implicated in pain perception, researchers have theorized that the overlapping responses to pain in the self and in others mark the human capacity for empathy. Here we investigated how prior exposure to extreme pain affects pain perception, by assessing the dynamics of pain processing in veterans who were previously exposed to severe injury. Fortythree participants (28 pain-exposed and 15 controls) underwent whole-head magnetoencephalography (MEG) while viewing photographs of limbs in painful and nonpainful (neutral) conditions. Among controls, an early (0-220 ms) Bpain effect^in the posterior cingulate and sensorimotor cortices, and a later (760-900 ms) Bpain effect^in the posterior cingulate cortex, superior temporal gyrus/insula, and fusiform gyrus were found, indicated by enhanced alpha suppression to the pain versus nonpain conditions. Importantly, pain-exposed participants exhibited an atypical pain response in the posterior cingulate cortex, indicated by a normative response to pain, but no pain-to-no-pain differentiation. This may suggest that individuals exposed to extreme pain may perceive neutral stimuli as potentially threatening. Our findings demonstrate alterations in pain perception following extreme pain exposure, chart the sequence from automatic to evaluative pain processing, and emphasize the importance of considering past experiences in studying the neural response to others' states.

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“…Brain imaging studies have also shown that acupuncture needle stimulation1718192021 can evoke widespread brain activity changes and modulate the functional connectivity (FC) of the pain processing network2223242526272829, which opens a new window to understand the central mechanism of acupuncture treatment.…”

mentioning

confidence: 99%

Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients

Chen

Spaeth

Retzepi

et al. 2014

Sci Rep

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In this study, we investigated cortical thickness and functional connectivity across longitudinal acupuncture treatments in patients with knee osteoarthritis (OA). Over a period of four weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before their first, third and sixth treatments. Clinical outcome showed a significantly greater Knee Injury and Osteoarthritis Outcome Score (KOOS) pain score (improvement) with verum acupuncture compared to the sham acupuncture. Longitudinal cortical thickness analysis showed that the cortical thickness at left posterior medial prefrontal cortex (pMPFC) decreased significantly in the sham group across treatment sessions as compared with verum group. Resting state functional connectivity (rsFC) analysis using the left pMPFC as a seed showed that after longitudinal treatments, the rsFC between the left pMPFC and the rostral anterior cingulate cortex (rACC), medial frontal pole (mFP) and periaquiduct grey (PAG) are significantly greater in the verum acupuncture group as compared with the sham group. Our results suggest that acupuncture may achieve its therapeutic effect on knee OA pain by preventing cortical thinning and decreases in functional connectivity in major pain related areas, therefore modulating pain in the descending pain modulatory pathway.

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Inserting Needles Into the Body: A Meta-Analysis of Brain Activity Associated With Acupuncture Needle Stimulation

Cited by 175 publications

References 63 publications

Psychophysical and neurophysiological responses to acupuncture stimulation to incorporated rubber hand

Psychophysical and neurophysiological responses to acupuncture stimulation to incorporated rubber hand

Prior exposure to extreme pain alters neural response to pain in others

Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients

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