Insertion/deletion polymorphism in intron 16 of the ACE gene and left ventricular hypertrophy in patients with end-stage renal disease

Osono, Eiichi; Kurihara, Susumu; Hayama, Naoaki; Sakurai, Yoshinori; Ohwada, Kei; Onoda, Noboru; Takeuchi, Masaaki; Tomizawa, Takuji; Komaba, Yuichi; Hashimoto, K; Matsunobu, Seiichi; Yoneshima, Hideo; Iino, Yoshimi

doi:10.1016/s0272-6386(98)70126-x

Cited by 37 publications

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“…In 12 case-control studies, 7,8,14 -17,21,32,36-39 patients with left ventricular hypertrophy and control subjects were selected from one of the following sampling frames (Table 1): the general population, 14,16,17,39 hypertensive patients examined at the out-patient clinic, 15,21,36 hospitalised patients with hypertension 7,8,38 or renal insufficiency, 37 or men in military service. 32 The definition of left ventricular hypertrophy varied widely among the 12 studies (Table 1).…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…Depending on the formula applied, the cut-off values for left ventricular hypertrophy ranged from The 12 case-control studies included 16 groups of which the characteristics are summarised in Table 2. With the exception of two studies in Japanese 15,37 and one American study 21 which included 25% of blacks, only whites were studied. 8,14,16,17,32,36,38,39 Of 16 groups, five included only men, 14,16,32,39 two included only women, 14,16 and eight had a mixed sex composition.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…8,14,16,17,32,36,38,39 Of 16 groups, five included only men, 14,16,32,39 two included only women, 14,16 and eight had a mixed sex composition. 7,8,15,17,21,[36][37][38] The sex ratio was not given for cases and controls in five reports. 7,8,15,37,38 Average age ranged from 18.9 32 to 61 7 years.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…7,8,15,17,21,[36][37][38] The sex ratio was not given for cases and controls in five reports. 7,8,15,37,38 Average age ranged from 18.9 32 to 61 7 years. In several studies it was impossible to evaluate whether cases and controls had been properly matched according to sex, age, body mass index, duration and severity of hypertension (Table 2).…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…42 Studies in which specific primers had been used 16,17,21,37 were contrasted with the remainder of the reports. 7,8,14,15,32,36,38,39 Odds of left ventricular hypertrophy associated with the D-allele In the first step of the analysis, allele frequencies were calculated (Table 3).…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

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Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis

et al. 2000

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This meta-analysis attempted to derive pooled estimates for the putative association between echocardiographic or electrocardiographic left ventricular hypertrophy and the deletion/insertion (D/I) polymorphism of the angiotensin-I converting enzyme. Casecontrol studies were combined, using the Mantel and Haenszel approach. Joint P-values for continuous variables were calculated by Stouffer's method. Continuous measurements of left ventricular mass, which were reported in different units, were expressed on a percentage scale using the within-study mean of the II genotype as the denominator. The computerised database used for this analysis, included 28 reports with an overall sample size of 6638 subjects. The prevalence of the D allele was significantly lower in Japanese (37.2%) than in Caucasians (56.2%). A funnel plot including 12 casecontrol studies (4094 subjects) suggested that no publication bias was present. Overall, left ventricular hypertrophy was not associated with the D allele. Compared with the II genotype, the excess risks of left ventricular hypertrophy associated with DD and DI geno-

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Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

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Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis

et al. 2000

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Genetic polymorphisms of the RAS-cytokine pathway and chronic kidney disease

2008

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Chronic kidney disease (CKD) in children is irreversible. It is associated with renal failure progression and atherosclerotic cardiovascular (CV) abnormalities. Nearly 60% of children with CKD are affected since birth with congenital or inherited kidney disorders. Preliminary evidence primarily from adult CKD studies indicates common genetic risk factors for CKD and atherosclerotic CV disease. Although multiple physiologic pathways share common genes for CKD and CV disease, substantial evidence supports our attention to the renin angiotensin system (RAS) and the interlinked inflammatory cascade because they modulate the progressions of renal and CV disease. Gene polymorphisms in the RAS-cytokine pathway, through altered gene expression of inflammatory cytokines, are potential factors that modulate the rate of CKD progression and CV abnormalities in patients with CKD. For studying such hypotheses, the cooperative efforts among scientific groups and the availability of robust and affordable technologies to genotype thousands of single nucleotide polymorphisms (SNPs) across the genome make genome-wide association studies an attractive paradigm for studying polygenic diseases such as CKD. Although attractive, such studies should be interpreted carefully, with a fundamental understanding of their potential weaknesses. Nevertheless, whole-genome association studies for diabetic nephropathy and future studies pertaining to other types of CKD will offer further insight for the development of targeted interventions to treat CKD and associated atherosclerotic CV abnormalities in the pediatric CKD population.

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Association of angiotensin-converting enzyme and endothelial Nitric Oxide synthase gene polymorphisms with vascular disease in ESRD patients in a Chinese population

2008

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Insertion/deletion polymorphism in intron 16 of the ACE gene and left ventricular hypertrophy in patients with end-stage renal disease

Cited by 37 publications

References 0 publications

Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis

Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis

Genetic polymorphisms of the RAS-cytokine pathway and chronic kidney disease

Association of angiotensin-converting enzyme and endothelial Nitric Oxide synthase gene polymorphisms with vascular disease in ESRD patients in a Chinese population

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