Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans

Abstract

No association was identified between I/D polymorphisms of ACE and SLE, LN, or GMN in a Mexican population.

Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism is not a risk factor for hypertension in SLE nephritis

“…In support to the above reports, Zhou et al in their meta-analysis found that the polymorphic ACE gene deletion allele was a genetic risk factor for SLE and development of lupus nephritis [21]. However, our findings are in agreement with the reports by Topete-Reyes et al, who suggested that the ACE insertion/ deletion polymorphism neither influenced the incidence of lupus nephritis nor the different histopathological classes of lupus nephritis in Mexican mestizos [22].…”

Association of angiotensin‐converting enzyme insertion/deletion polymorphism with susceptibility to systemic lupus erythematosus: a meta‐analysis

“…The process for selecting the studies is shown in Figure . One hundred and ninety potentially relevant records were first reviewed, and a total of 23 studies meeting the inclusion criteria were finally identified in the meta‐analysis . Among these recruited investigations, three were published in Chinese, and the others were reported in English.…”

“…Therefore, a total of 27 separate comparisons were considered in the meta‐analysis involving 2718 patients and 3655 controls. Fifteen studies involved Asian populations, seven studies involved European populations, three investigations involved African populations, one study each examine South American and North American populations . Characteristics of studies discussing the correlation between ACE I/D polymorphisms with SLE are presented in Table .…”

“…For example, Topete‐Reyes et al . showed no association between I/D polymorphism of ACE and SLE in a Mexican population . To better give insights into the association between this polymorphism and SLE/LN disease risk, a pooled analysis with a large subgroup sample exploring heterogeneity is needed.…”

“…One hundred and ninety potentially relevant records were first reviewed, and a total of 23 studies meeting the inclusion criteria were finally identified in the meta-analysis. [8][9][10][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Among these recruited investigations, three were published in Chinese, 23,29,32 and the others were reported in English. One of the eligible studies contained data on three different ethnic groups, 25 and two included data on two different groups, 21,31 and these were treated independently.…”