Inside Back Cover: Strain‐Promoted Reaction of 1,2,4‐Triazines with Bicyclononynes (Chem. Eur. J. 41/2015)

Abstract

A new (very slow) entrant in the bio‐orthogonal reaction race 1,2,4,5‐Tetrazines react rapidly with a wide range of strained dienophiles; however, the corresponding reactions of 1,2,4‐triazines have not all been evaluated. In their Full Paper on , M. E. Webb et al. report the synthesis of 1,2,4‐triazinylalanine and show that while it does react with bicyclononynes (but not norbonenes), the reaction rate is orders of magnitude slower than that for the corresponding tetrazines.