2020
DOI: 10.1002/ppul.24981
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Insight into the pediatric and adult dichotomy of COVID‐19: Age‐related differences in the immune response to SARS‐CoV‐2 infection

Abstract: The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric‐specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is critical for the development of vaccination strategies, immune‐targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune re… Show more

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Cited by 46 publications
(30 citation statements)
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“…These laboratory findings are suggestive of a “cytokine storm,” 58 similar to that reported in adults, but the presentation of MIS has been delayed until after the peak of SARS‐CoV‐2 cases in each city where it has been reported 66 . It is therefore considered to be an immunologically mediated inflammation syndrome, associated with an earlier SARS‐CoV‐2 infection 60,67 .…”
Section: Methodsmentioning
confidence: 63%
“…These laboratory findings are suggestive of a “cytokine storm,” 58 similar to that reported in adults, but the presentation of MIS has been delayed until after the peak of SARS‐CoV‐2 cases in each city where it has been reported 66 . It is therefore considered to be an immunologically mediated inflammation syndrome, associated with an earlier SARS‐CoV‐2 infection 60,67 .…”
Section: Methodsmentioning
confidence: 63%
“…Many children frequently develop fevers because they are vulnerable due to the weaker immune system and thus have a higher susceptibility for infections [ 15 ]. With the recent COVID-19 pandemic, the uses of analgesics and antipyretics are increasing rapidly to resolve instances of high fever, which is one of the major symptoms of the infection [ 16 ]. In children with a fever, the average intake of analgesics and antipyretics was once every 8 h or 10 times a week [ 17 ].…”
Section: Discussionmentioning
confidence: 99%
“…Some cases are classified as moderate disease due to radiological findings, although the symptoms are few (2,7,59). The recovery is faster probably due to lower affectation and a better immune response (60), but complications in the presence of co-morbidities are more likely (10,61,62). Although mortality in cases requiring pediatric intensive care units (PICU) is low (12,63), an increase is being observed.…”
Section: Clinical Presentationmentioning
confidence: 99%