Insight on updates in polysaccharides for ocular drug delivery

Chandra, Nittala Sarath; Gorantla, Srividya; Priya, Sakshi; Singhvi, Gautam

doi:10.1016/j.carbpol.2022.120014

Cited by 29 publications

(10 citation statements)

References 54 publications

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Section: Fabrication Of Nanofibersmentioning

confidence: 99%

“…Natural origin polymers belonging to proteins such as gelatin, collagen, and polysaccharides like chitosan, cellulose, dextran, hyaluronic acid, and alginate are most commonly used in nanofibers so far with a wide range of applications. 20 Gelatin electrospun nanofibers scaffold containing tellurium nanoparticles were developed for wound dressing to avoid immunogenic responses due to the natural origin of gelatin. 21 Also in another experiment, gelatin was combined with bacterial cellulose to produce nanofibers and was tested for diabetic wound healing achieving a system made up of an all-natural polymer construct.…”

Section: Fabrication Of Nanofibersmentioning

confidence: 99%

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Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

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Nanotechnology has yielded nanostructure-based drug delivery approaches, among which nanofibers have been explored and researched for the potential topical delivery of therapeutics. Nanofibers are filaments or thread-like structures in the nanometer size range that are fabricated using various polymers, such as natural or synthetic polymers or their combination. The size or diameter of the nanofibers depends upon the polymers, the techniques of preparation, and the design specification. The four major processing techniques, phase separation, self-assembly, template synthesis, and electrospinning, are most commonly used for the fabrication of nanofibers. Nanofibers have a unique structure that needs a multimethod approach to study their morphology and characterization parameters. They are gaining attention as drug delivery carriers, and the substantially vast surface area of the skin makes it a potentially promising strategy for topical drug products for various skin disorders such as psoriasis, skin cancers, skin wounds, bacterial and fungal infections, etc. However, the large-scale production of nanofibers with desired properties remains challenging, as the widely used electrospinning processes have certain limitations, such as poor yield, use of high voltage, and difficulty in achieving in situ nanofiber deposition on various substrates. This review highlights the insights into fabrication strategies, applications, recent clinical trials, and patents of nanofibers for different skin disorders in detail. Additionally, it discusses case studies of its effective utilization in the treatment of various skin disorders for a better understanding for readers.

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Section: Fabrication Of Nanofibersmentioning

confidence: 99%

Section: Fabrication Of Nanofibersmentioning

confidence: 99%

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ [354][355][356] in the early stages of therapy (Figure 23Biii). Furthermore, TGNPs improve tear production and reduce eye inflammation, indicating their safety and efficacy for treating dry eye disease (DED).…”

Section: Ggmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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“…Gelrite ® is an easy-to-find product that gels when it comes in touch with either monovalent or divalent cations. When given as a liquid into the culde-sac, the cations Na + , Mg 2+ , and Ca 2+ in the electrolytes of tear fluid have been shown to cause polymer gel to form (Chandra et al 2022). When the right amount of calcium gluconate was added to gellan compositions, gellan calcium gluconate-STF gels were made that were much stronger than gellan-STF mixes that did not have calcium gluconate.…”

Section: Gellan Gummentioning

confidence: 99%

Revolutionizing ocular drug delivery: recent advancements in in situ gel technology

Paul,

Majumdar,

Chakraborty

2023

Bull Natl Res Cent

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Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug. The main body of the abstract Among drug delivery modalities, ocular drug administration requires careful study and parameter assessment. This is because the eyes are sensitive and require careful care. Conventional ocular administration techniques quickly eliminate formulated compounds, minimizing epithelial interaction. This review covers polymers used in ocular medication delivery, their uses, and their drawbacks. The in situ gelling mechanism converts liquid formulations into gels under certain physiological or environmental conditions. When they contact the ocular surface, in situ ocular gels undergo this transformation for medication administration. Different mechanisms drive this change, depending on the gel's formulation and desired properties. Temperature-, pH-, and ion-induced gelation are common processes of in situ ocular gel formation. The medicine's physicochemical qualities, desired drug release kinetics, ocular environment, and patient comfort determine the mechanism. Researchers can create ocular gels that transport medications, improve bioavailability, and increase patient compliance by carefully formulating and understanding the in situ gelation mechanism. These polymers are useful in prodrug research and ocular penetration enhancement. The article thoroughly discusses polymeric systems and creates a viable ophthalmic drug delivery formulation. Short conclusion In conclusion, in situ ocular gels advance ocular medication delivery. These gels overcome various difficulties of current delivery strategies for ocular therapeutics and provide a diverse and effective platform. In situ gelling, where the liquid formulation becomes a gel when it contacts ocular tissues, improves medication retention, bioavailability, and contact time.

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Insight on updates in polysaccharides for ocular drug delivery

Cited by 29 publications

References 54 publications

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Revolutionizing ocular drug delivery: recent advancements in in situ gel technology

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