In recent years, the world has faced a rapid rise in humanitarian needs and an increasing risk of famine. Given the potential threats posed by conflict, climate change, economic shocks, and other issues, it is important to be prepared for the possibility of new crises in the future. Drawing on key informant interviews and a literature review, this paper assesses the state of the art in famine prevention, examining a range of technical and political approaches and analysing emerging lessons. Based on the findings, it identifies five levels of famine prevention: (i) averting famine; (ii) anticipating famine; (iii) reducing famine risks; (iv) altering famine risks; and (v) preventing famine risks. The paper argues that the current focus only partially addresses a relatively narrow set of levels. It concludes that a more comprehensive approach that engages all five levels simultaneously could contribute to a global famine prevention framework for the twenty‐first century and beyond.