Insights into collateral susceptibility and collateral resistance in
            <i>Acinetobacter baumannii</i>
            during antimicrobial adaptation

Dawan, Jirapat; Kim, Jin‐Chul; Ahn, Juhee

doi:10.1111/lam.13488

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…2017; Dawan et al . 2021), no report has observed the same phenomenon using natural compounds except one case study (Bischofberger et al . 2021).…”

Section: Resultsmentioning

confidence: 90%

“…The sensitization and re-sensitization of resistant bacteria to antibiotics and other stresses have been observed early, involving weakening or interrupting bacterial defense mechanisms (Repaske 1958;Vaara and Vaara 1983;Helander et al 2001). While the collateral sensitivity of bacteria to an antibiotic was found to develop during the adaptation of the bacteria to other types of antimicrobial drugs (Barbosa et al 2017;Dawan et al 2021), no report has observed the same phenomenon using natural compounds except one case study (Bischofberger et al 2021). The collateral sensitivity is theoretically feasible and might direct the evolution trajectories and counteract the antibiotic-resistant mechanisms (Rodriguez de Evgrafov et al 2015).…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial resistance tendency and collateral sensitivity of Staphylococcus aureus adapted to antibiotics or extracts of medicinal plants grown in Viet Nam

Nguyen

Thi

Diep

et al. 2022

Letters in Applied Microbiology

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Significance and Impact of the Study: Plant-derived antimicrobial natural compounds (PNACs) have been considered as alternatives to antibiotics in fighting pathogenic bacteria. However, evidence on the low resistance tendency of PNACs is very limited, and the synergistic antimicrobial activity of PNACs and antibiotics has been demonstrated in co-treatment only. It is the first time that the collateral relationship between bacterial adaptation and resistance to PNACs and antibiotics has been reported.

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“…2017; Dawan et al . 2021), no report has observed the same phenomenon using natural compounds except one case study (Bischofberger et al . 2021).…”

Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Antimicrobial resistance tendency and collateral sensitivity of Staphylococcus aureus adapted to antibiotics or extracts of medicinal plants grown in Viet Nam

Nguyen

Thi

Diep

et al. 2022

Letters in Applied Microbiology

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show abstract

“…This suggests that the single–drug–treated lineages collected in this study adapted to the antibiotics (CIP and PMB) without mutation [ 44 ]. Consequently, the collateral susceptibility observed in this study can be attributed to the pre–adaptation phenomenon, which has been found to be associated with beta–lactamase and efflux pump activities [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Drug Combination of Ciprofloxacin and Polymyxin B for the Treatment of Multidrug–Resistant Acinetobacter baumannii Infections: A Drug Pair Limiting the Development of Resistance

et al. 2023

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Polymyxins are considered as last–resort antibiotics to treat infections caused by Acinetobacter baumannii. However, there are increasing reports of resistance in A. baumannii to polymyxins. In this study, inhalable combinational dry powders consisting of ciprofloxacin (CIP) and polymyxin B (PMB) were prepared by spray–drying. The obtained powders were characterized with respect to the particle properties, solid state, in vitro dissolution and in vitro aerosol performance. The antibacterial effect of the combination dry powders against multidrug–resistant A. baumannii was assessed in a time–kill study. Mutants from the time–kill study were further investigated by population analysis profiling, minimum inhibitory concentration testing, and genomic comparisons. Inhalable dry powders consisting of CIP, PMB and their combination showed a fine particle fraction above 30%, an index of robust aerosol performance of inhaled dry powder formulations in the literature. The combination of CIP and PMB exhibited a synergistic antibacterial effect against A. baumannii and suppressed the development of CIP and PMB resistance. Genome analyses revealed only a few genetic differences of 3–6 SNPs between mutants and the progenitor isolate. This study suggests that inhalable spray–dried powders composed of the combination of CIP and PMB is promising for the treatment of respiratory infections caused by A. baumannii, and this combination can enhance the killing efficiency and suppress the development of drug resistance.

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Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae

Yang

et al. 2023

Drug Resistance Updates

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Insights into collateral susceptibility and collateral resistance in Acinetobacter baumannii during antimicrobial adaptation

Cited by 4 publications

References 36 publications

Antimicrobial resistance tendency and collateral sensitivity of Staphylococcus aureus adapted to antibiotics or extracts of medicinal plants grown in Viet Nam

Antimicrobial resistance tendency and collateral sensitivity of Staphylococcus aureus adapted to antibiotics or extracts of medicinal plants grown in Viet Nam

Drug Combination of Ciprofloxacin and Polymyxin B for the Treatment of Multidrug–Resistant Acinetobacter baumannii Infections: A Drug Pair Limiting the Development of Resistance

Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae

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