Insights into regeneration tool box: An animal model approach

Mehta, Abijeet Singh; Singh, Amit

doi:10.1016/j.ydbio.2019.04.006

Cited by 48 publications

(70 citation statements)

References 262 publications

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“…As was mentioned in previous sections, regeneration is about re-establishing the structure and form of the tissue, organ, or organism via different modes such as the application of adult stem cells (66). Also, it varies from whole-body to cellular regeneration.…”

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

“…Additionally, there are common pathways which have regulatory roles in the regeneration responses of different species including Wnt and Notch pathways. Misregulation of these pathways can cause cancerous tissue in humans (66). In other words, it seems that evolution related to the downregulation of regeneration responses can have a preventive effect on developing cancers in humans.…”

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

“…In fact, it can be due to increased complexity of tissues and metabolism in mammals because of the dependence of mammal regeneration responses on age and tissue changes. However, the exact mechanisms are not fully understood (66,67). Hence, understanding the mechanisms of regeneration and endogenous tissue repair is of great importance in the prospects of regenerative medicine (67).…”

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

“…Hence, understanding the mechanisms of regeneration and endogenous tissue repair is of great importance in the prospects of regenerative medicine (67). Accordingly, zebrafish is considered as an informative animal model for regenerative medicine due to its beneficial features including highly regenerative capacity and amenability to genetic manipulation, which makes it a therapeutic model for organ development and diseases, despite its limitations such as gene duplications (61,66,68). Further, zebrafish has become more and more popular in modeling human diseases for understanding the effects of genetic mutations, environmental disturbances, and drug development (69).…”

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

“…Generally, zebrafish promotes the understanding of the underlying processes of DM pathogenesis for therapeutic approaches. In addition, due to its various potential benefits like regenerative capacity and its application in other areas of personalized medicine, it can be suggested as a personalized tool in this field (9,63,66).…”

Section: Zebrafish Model To Study Diabetesmentioning

confidence: 99%

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Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

Section: Humanized Zebrafish Model For Personalized Regenerative Medimentioning

confidence: 99%

Section: Zebrafish Model To Study Diabetesmentioning

confidence: 99%

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Decellularized Biohybrid Nerve Promotes Motor Axon Projections

Mehta,

Zhang,

Xie

et al. 2024

Adv Healthcare Materials

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Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, biohybrid nerves are developed using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4‐ethylenedioxythiophene) (PEDOT). Nine biohybrid nerves are compared with varying polymerization conditions and cycles, selecting the best candidate through material characterization. These results show that a 1:1 ratio of FeCl3 oxidant to ethylenedioxythiophene (EDOT) monomer, cycled twice, provides superior conductivity (>0.2 mS cm−1), mechanical alignment, intact mesostructures, and high compatibility with cells and blood. To test the biohybrid nerve's effectiveness in promoting motor axon growth, human Spinal Cord Spheroids (hSCSs) derived from HUES 3 Hb9:GFP cells are used, with motor axons labeled with green fluorescent protein (GFP). Seeding hSCS onto one end of the conduit allows motor axon outgrowth into the biohybrid nerve. The construct effectively promotes directed motor axon growth, which improves significantly after seeding the grafts with Schwann cells. This study presents a promising approach for reconstructing axonal tracts in humans.

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