2016
DOI: 10.1080/1061186x.2016.1221956
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Insights into the percutaneous penetration of antidiabetic agents

Abstract: It has been suggested that destruction of β cells through apoptosis leads to type 1 diabetes (T1DM) while type 2 diabetes (T2DM) is caused mainly by increased insulin resistance. Several therapeutic agents are available for the management of diabetes. While researchers continue to investigate disease-modifying compounds, it is also important to develop alternative drug delivery systems for existing medications with the goal of modulating bioavailability and/or pharmacokinetic half-life. Transdermal drug delive… Show more

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Cited by 4 publications
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“…Furthermore, dosage accuracy could become more difficult to measure when compared to hypodermic needles [12]. Currently, neither microneedles nor microneedle rollers are available for clinical use [49]. However, a microneedle patch loaded with an inactivated influenza vaccine is currently undergoing clinical trials [50].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, dosage accuracy could become more difficult to measure when compared to hypodermic needles [12]. Currently, neither microneedles nor microneedle rollers are available for clinical use [49]. However, a microneedle patch loaded with an inactivated influenza vaccine is currently undergoing clinical trials [50].…”
Section: Introductionmentioning
confidence: 99%