Insights into the Perspective Correlation Between Vitamin D and Regulation of Hormones: Thyroid and Parathyroid Hormones

Abed, Mohammed N.; Alassaf, Fawaz A.; Qazzaz, Mohannad E.; Alfahad, Mohanad; Jasim, Mahmood H. M.

doi:10.1007/s12018-021-09279-6

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…[14] We have previously reported diverse roles for ViD in affecting multiple diseases and hormones, including allergic rhinitis, thyroid hormones, parathyroid hormones, sex hormones, prolactin, adrenal hormones, and vasopressin. [15][16][17][18][19][20] ViD , s involvement in the mechanisms underlying the development of Ins-R and obesity among diabetic individuals has recently been documented. The vitamin might help to provide better glycemic control through increasing glucose uptake, in addition to stimulating the secretion of insulin.…”

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confidence: 99%

Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health

Abed,

Alassaf,

Qazzaz

2024

J Bone Metab

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Vitamin D (ViD), plays an important role in calcium absorption and bone mineralization, is associated with bone mineral density. Severe deficiency in ViD has long been linked to conditions such as rickets in children and osteomalacia in adults, revealing its substantial role in skeletal health. Additionally, investigations show an existing interconnection between ViD and insulin resistance (Ins-R), especially in patients with type 2 diabetes mellitus (T2DM). Obesity, in conjunction with Ins-R, may augment the risk of osteoporosis and deterioration of skeletal health. This review aims to examine recent studies on the interplay between ViD, Ins-R, obesity, and their impact on skeletal health, to offer insights into potential therapeutic strategies. Cochrane Library, Google Scholar, and Pubmed were searched to investigate relevant studies until December 2023. Current research demonstrates ViD’s impact on pancreatic β-cell function, systemic inflammation, and insulin action regulation. Our findings highlight an intricate association between ViD, Ins-R, obesity, and skeletal health, providing a perspective for the prevention and/or treatment of skeletal disorders in patients with obesity, Ins-R, and T2DM.

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Section: Introductionmentioning

confidence: 99%

Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health

Abed,

Alassaf,

Qazzaz

2024

J Bone Metab

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Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations

Zaki,

Abed,

Alassaf

2024

J Bone Metab

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Diabetes mellitus is associated with inadequate bone health and quality and heightened susceptibility to fractures, even in patients with normal or elevated bone mineral density. Elevated advanced glycation end-products (AGEs) and a suppressed incretin pathway are among the mechanisms through which diabetes affects the bone. Accordingly, the present review aimed to investigate the effects of antidiabetic medications on bone quality, primarily through AGEs and the incretin pathway. Google Scholar, Cochrane Library, and PubMed were used to examine related studies until February 2024. Antidiabetic medications influence AGEs and the incretin pathway directly or indirectly. Certain antidiabetic drugs including metformin, glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl-peptidase-4 (DDP-4) inhibitors, α-glucosidase inhibitors (AGIs), sodium-glucose co-transporter-2 inhibitors, and thiazolidinediones (TZDs), directly affect AGEs through multiple mechanisms. These mechanisms include decreasing the formation of AGEs and the expression of AGEs receptor (RAGE) in tissue and increasing serum soluble RAGE levels, resulting in the reduced action of AGEs. Similarly, metformin, GLP-1RA, DDP-4 inhibitors, AGIs, and TZDs may enhance incretin hormones directly by increasing their production or suppressing their metabolism. Additionally, these medications could influence AGEs and the incretin pathway indirectly by enhancing glycemic control. In contrast, sulfonylureas have not demonstrated any obvious effects on AGEs or the incretin pathway. Considering their favorable effects on AGEs and the incretin pathway, a suitable selection of antidiabetic drugs may facilitate more protective effects on the bone in diabetic patients.

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Effects of resistance and strength training on serum phosphorus levels in male footballers: implications for physical educators and sports trainers

Mustafa,

Khan,

Arif

et al. 2024

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Background and Study Aim. Sports performance and overall health of athletes are highly dependent on various physiological markers. Among these, blood biochemistry is of great importance and should be carefully considered in athletes' training regimens. However, the effect of strength and resistance training on serum phosphorus levels still requires further clarification and more effective solutions. The aim of this study was to determine the effect of strength and resistance training on serum phosphorus levels in elite male soccer players. Material and Methods. A sample of 90 volunteers was recruited from football athletes in the Peshawar division. Thirty participants were selected from each of the under-16, under-19, and under-23 age groups. They were divided into three groups: the Resistance Training Group (RTG), the Strength Training Group (STG), and the Control Group (CG). Each group consisted of 30 participants, with 10 from each age category. Phosphorus levels and anthropometric measurements (height, weight, BMI, waist circumference, hip circumference, and waist-to-hip ratio (WHR)) were assessed before and after a 12-week strength and resistance training intervention. Analysis of Variance (ANOVA) and paired sample t-tests were used to evaluate changes over time. Results. Significant improvements were observed in serum phosphorus levels in the Resistance Training Group (4.77±0.258 vs. 3.66±0.207, P<0.001) and in the Strength Training Group (4.31±0.304 vs. 3.66±0.209, P<0.001). A 12-week regimen of strength and resistance training significantly improved serum phosphorus levels among the participants. Analysis of variance indicated that both strength and resistance training significantly affected serum phosphorus levels after 12 weeks of intervention. Tukey’s HSD test revealed that the effects of resistance training were more pronounced than those of strength training. Conclusions. This study highlights the importance of incorporating both strength and resistance training in athletic programs. These training approaches are crucial for optimizing physical health and performance. The findings underscore the need for educators and trainers to adapt and refine their methods to maximize the benefits of these interventions. By doing so, they can enhance the effectiveness of training regimens and contribute to the overall well-being of athletes.

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Insights into the Perspective Correlation Between Vitamin D and Regulation of Hormones: Thyroid and Parathyroid Hormones

Cited by 3 publications

References 73 publications

Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health

Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health

Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations

Effects of resistance and strength training on serum phosphorus levels in male footballers: implications for physical educators and sports trainers

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