Insights into the relationship between serum uric acid and pulmonary hypertension (Review)

Abstract

Pulmonary hypertension (PH) is a progressive lethal disease, which is characterized by abnormal vascular remodeling and persistently elevated pulmonary artery pressure, eventually leading to right heart failure and even death. although great progress has been made in treating PH, the mortality rate remains high. Metabolic disorders are one of the important hallmarks of PH. obesity, lipids, glucose tolerance and insulin resistance are risk factors for numerous cardiovascular diseases and are often accompanied by a considerable increase in serum uric acid (Sua) concentrations. uric acid (ua) is the end product of purine nucleotide metabolism and is closely related to cardiovascular diseases including PH. Hyperuricemia promotes the development and progression of PH through endothelial dysfunction, oxidative stress, inflammatory responses and activation of the renin-angiotensin system. in the present review, the advancements in knowledge about ua metabolism and PH, and the current understanding of the potential interactions and mechanisms of Sua in PH were systematically summarized, which may provide new insights into the pathogenesis of PH.

Hyperuricemia is strongly associated with pulmonary hypertension in chronic lung disease

“…The pathophysiological mechanisms underlying the relationship between hyperuricemia and PH associated with chronic lung diseases (WHO group 3) are not fully understood. The main proposed cause of elevated serum uric acid in patients with severe chronic pulmonary disease is tissue hypoxia [5,10]. Speci cally, uric acid is the nal product of xanthine-oxidase-generated purine metabolism, and tissue hypoxia increases this process by inducing a decrease in adenosine triphosphate synthesis [5,10].…”

“…The main proposed cause of elevated serum uric acid in patients with severe chronic pulmonary disease is tissue hypoxia [5,10]. Speci cally, uric acid is the nal product of xanthine-oxidase-generated purine metabolism, and tissue hypoxia increases this process by inducing a decrease in adenosine triphosphate synthesis [5,10]. An additional contributing factor of hyperuricemia in patients with chronic lung disease may be concomitant metabolic syndrome and renal dysfunction [5,13].…”

“…Hyperuricemia may itself play a role in the development of PH in chronic lung diseases. Firstly, hyperuricemia induces endothelial dysfunction by decreasing the production of nitric oxide [5,10,14]. As a result, the release of various vasoactive substances and cytokines from endothelial cells is increased, leading to pulmonary vasoconstriction and the development of PH [5,10,15].…”

“…A variety of biomarkers, including serum uric acid, are recommended for the assessment of established PH [4]. Elevated serum levels of uric acid are commonly observed in patients with World Health Organization (WHO) group 1 PH (pulmonary arterial hypertension) and strongly correlate with disease severity [5][6][7][8][9][10]. However, information regarding the relationship of serum uric acid with PH associated with chronic lung diseases (WHO Group 3) is scarce.…”

Postbiotic of Pediococcus acidilactici GQ01, a Novel Probiotic Strain Isolated from Natural Fermented Wolfberry, Attenuates Hyperuricaemia in Mice through Modulating Uric Acid Metabolism and Gut Microbiota

“…Generally, male patients are more likely than female patients, and the age of patients tends to be younger [ 3 , 4 ]. HUA is also accompanied by complications such as gout [ 5 ], chronic kidney disease [ 6 ], obesity [ 7 ], diabetes [ 8 ], and hypertension [ 9 ]. HUA is a significant risk to individuals’ well-being and health and increases the public health burden on society.…”