Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report

Abstract

Agents of platinum-based chemotherapy, such as cisplatin or carboplatin, are used in the treatment of a wide range of malignancies that affect children, such as brain tumors, osteosarcoma, neuroblastoma, hepatoblastoma, and germ cell tumors (GCTs). The Cyclophosphamide Equivalent Dose (CED) calculator for reproductive risk does not take platinum-based chemotherapy into account, despite the fact that it accounts for the majority of chemotherapy medications that are typically administered for pediatric GCTs. As a result, exposure to platinum-based drugs throughout infancy can have predictable long-term effects such as infertility, as well as other rare encounters such as lipoma formation and lipomatosis. Lipomas are the most prevalent benign soft tissue tumor subtype. They may be either solitary entities or engaged in multiple lipomatosis, which may have a familial origin or be an acquired disorder. Chemotherapy is a possible cause of lipomatosis. Chemotherapy based on cisplatin has been linked to a variety of long-term consequences, including kidney damage, neurotoxicity, and pulmonary toxicity, and may even create secondary cancers. However, lipoma development is known to occur in fewer than 1 in 100 individuals, and only a few examples of multiple cutaneous lipomatosis triggered by this therapy have been documented. Here we present a very rare case of lipomatosis in a pediatric patient with GCT under cisplatin therapy, which might be the third report of this kind affecting children.

Importance of Multimodality Cardiac Imaging in the Diagnosis of Lipomatous Hypertrophy of the Interatrial Septum—A View beyond Standard Situations

“…There are several reports that demonstrate such an association as well as with obesity, which was also concordant in our case [2,10,15]. Boeriu E. et al reported generalized lipomatosis induced by chemotherapy with platinum agents in a 16-year-old girl treated for teratoma [16]. Given the fact that our patient was unaware of this problem until now and she lacked any previous imaging results that could describe it, we even thought about a possible reaction of the IAS in relation to the chemotherapy catheter.…”

Assessing Botulinum Toxin Effectiveness and Quality of Life in Axillary Hyperhidrosis: A One-Year Prospective Study

“…This finding emphasizes the need for a holistic approach in treating hyperhidrosis, addressing both the physical symptoms and the broader psychological and social effects of the condition. Moreover, even though the current study addressed only the cases of primary hyperhidrosis, patients affected by secondary hyperhidrosis from various causes [17][18][19] might have a worsened quality of life that deserves medical attention.…”

A Prospective Analysis of the Retinopathy of Prematurity Correlated with the Inflammatory Status of the Extremely Premature and Very Premature Neonates

“…Retinopathy of Prematurity (ROP) is a potentially blinding eye disorder [ 1 , 2 ] that primarily affects premature infants, particularly those born extremely premature, before 28 weeks gestation, or very premature, between 28 to 32 weeks of gestation [ 3 , 4 ]. It is characterized by the abnormal growth of blood vessels in the retina, which can lead to retinal detachment and, eventually, blindness if left untreated [ 5 , 6 , 7 ]. The prevalence of ROP has increased significantly in recent years due to the improved survival rates of premature infants, making it an important public health concern [ 8 ].…”