Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer

Salehi, Bahare; Fokou, Patrick Valère Tsouh; Yamthé, Lauve Rachel Tchokouaha; Tali, Brice Tchatat; Adetunji, Charles Oluwaseun; Rahavian, Amirhossein; Mudau, Fhatuwani Nixwell; Martins, Natália; Martorell, Miquel; Rodrigues, Célia Fortuna; Setzer, William N.; Sharifi‐Rad, Mehdi; Amarowicz, Ryszard; Sharifi‐Rad, Javad

doi:10.14715/cmb/2020.66.4.30

Cited by 4 publications

(2 citation statements)

References 103 publications

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“…Meanwhile, some treatments for liver cancer, such as chemotherapy, have been proven to have serious side effects [10,11]. Thus, there is great interest in finding effective and safe anticancer substances from natural products, especially nutraceuticals and functional foods [12].…”

Section: Introductionmentioning

confidence: 99%

Enrichment and Evaluation of Antitumor Properties of Total Flavonoids from Juglans mandshurica Maxim

Yang,

Chu,

et al. 2024

Molecules

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Flavonoids are important secondary metabolites found in Juglans mandshurica Maxim., which is a precious reservoir of bioactive substances in China. To explore the antitumor actions of flavonoids (JMFs) from the waste branches of J. mandshurica, the following optimized purification parameters of JMFs by macroporous resins were first obtained. The loading concentration, flow rate, and loading volume of raw flavonoid extracts were 1.4 mg/mL, 2.4 BV/h, and 5 BV, respectively, and for desorption, 60% ethanol (4 BV) was selected to elute JMFs-loaded AB-8 resin at a flow rate of 2.4 BV/h. This adsorption behavior can be explained by the pseudo-second-order kinetic model and Langmuir isotherm model. Subsequently, JMFs were identified using Fourier transform infrared combined with high-performance liquid chromatography and tandem mass spectrometry, and a total of 156 flavonoids were identified. Furthermore, the inhibitory potential of JMFs on the proliferation, migration, and invasion of HepG2 cells was demonstrated. The results also show that exposure to JMFs induced apoptotic cell death, which might be associated with extrinsic and intrinsic pathways. Additionally, flow cytometry detection found that JMFs exposure triggered S phase arrest and the generation of reactive oxygen species in HepG2 cells. These findings suggest that the JMFs purified in this study represent great potential for the treatment of liver cancer.

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Section: Introductionmentioning

confidence: 99%

Enrichment and Evaluation of Antitumor Properties of Total Flavonoids from Juglans mandshurica Maxim

Yang,

Chu,

et al. 2024

Molecules

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“…Epidemiological studies have consistently shown that increased dietary intake of fruits and vegetables is strongly associated with a reduced risk of developing chronic diseases such as cardiovascular disease, diabetes and cancer (3,4). Long-term intake treatment with anti-cancer plant foods is effective in reducing the patient's illness and recurrence rate of cancer compared to traditional methods of cancer treatment (5,6). Cauliflower, also known as broccoli, brassica, and tender stem cauliflower, contains high levels of sulforaphane (SFN) (7).…”

Section: Introductionmentioning

confidence: 99%

Cauliflower bioactive compound sulforaphane inhibits breast cancer development by suppressing NF-κB /MMP-9 signaling pathway expression

Zhou¹,

Zhou²,

Tong³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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In recent years, anti-cancer plant food development and research have received increasing attention, and cauliflower is one of the vegetables with anti-cancer effects. Sulforaphane (SFN) is one of the main anticancer components in cauliflower. In this study, the mechanism of action of SFN in anti-breast cancer was investigated using SFN, a bioactive compound extracted from cauliflower. For this purpose, SFN was extracted from cauliflower using rotary evaporation and silica gel chromatography, and the extracted SFN was used for in vitro and in vivo experiments. Breast cancer cells MCF-7, MDA-MB-231 and MDA-MB-231 xenograft tumor model mice were treated with SFN, pcDNA3.1-MMP-9, Si-RNA-MMP-9 and Si-RNA-NF-κB, respectively, and the corresponding saline treatment or blank plasmid treatment was used as control. The gene expression of NF-κB and MMP-9 in each group was detected by RT-PCR, and the protein phosphorylation level of MMP-9 was measured by Western bloting assay. WST 1 assay, MTT assay and flow cytometric analysis were used to detect the activity, proliferation and apoptosis levels of breast cancer cells. The tumor histopathology of the xenograft tumor model mice after SFN treatment was examined by HE staining. Results showed that Breast cancer cells treated with SFN showed reduced cell proliferation, decreased cell activity, increased apoptosis ratio, and inhibited gene expression and protein phosphorylation of MMP-9 as well as gene expression of NF-κB (P < 0.05). The same effect occurred with transfection of Si-RNA-MMP-9 and Si-RNA-NF-κB in breast cancer cells, while transfection of pcDNA3.1-MMP-9 plasmid significantly redeemed the inhibitory effect of SFN on breast cancer cells (P < 0.05). MDA-MB-231 xenograft tumor model mice treated with SFN showed significant improvement in the pathological condition of the tumor tissue. Then, SFN may inhibit breast cancer development by regulating the NF-κB /MMP-9 signaling pathway.

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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Tuli

Mittal

Loka

et al. 2021

Pharmacological Research

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Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer

Cited by 4 publications

References 103 publications

Enrichment and Evaluation of Antitumor Properties of Total Flavonoids from Juglans mandshurica Maxim

Enrichment and Evaluation of Antitumor Properties of Total Flavonoids from Juglans mandshurica Maxim

Cauliflower bioactive compound sulforaphane inhibits breast cancer development by suppressing NF-κB /MMP-9 signaling pathway expression

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

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