Insights on the neural basis of motor plasticity induced by theta burst stimulation from <scp>TMS</scp>–<scp>EEG</scp>

Vernet, Marine; Bashir, Shahid; Yoo, Woo‐Kyoung; Perez, Jennifer; Najib, Umer; Pascual‐Leone, Álvaro

doi:10.1111/ejn.12069

Cited by 85 publications

(71 citation statements)

References 39 publications

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“…For example, Vernet et al (2013) have shown that the effects of theta-burst stimulation effects waver over time, indicating that additional factors, such as fluctuations in attention, emotional state and arousal, interact with the TMS-induced changes on cortical excitability levels over time (Schutter et al, 2001;Vernet et al, 2013Vernet et al, , 2014Monte-Silva et al, 2009). Such oscillating patterns are also seen in some PAS studies (Grundey et al, 2012a;Kuo et al, 2007;Nitsche et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry

Wischnewski

Schutter

2016

Clinical Neurophysiology

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Section: Discussionmentioning

confidence: 99%

Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry

Wischnewski

Schutter

2016

Clinical Neurophysiology

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“…Studies sometimes make such implicit assumptions, but the field is lacking a fundamental insight to accept or modify such assumptions. Encouraging advances have been made on this end for TMS (Thut & Miniussi, 2009;Thut & Pascual-Leone, 2009;Vernet et al, 2013), transcranial alternating current stimulation (tACS; Fröhlich & McCormick, 2010;Herrmann, Rach, Neuling, & Strüber, 2013), and direct brain stimulation (Logothetis et al, 2010;Tolias et al, 2005). For example, Vernet et al(2013) used a combined TMS-EEG approach to evaluate the cortical effects of continuous theta-burst stimulation (cTBS).…”

Section: The Road Ahead: Additional Considerations Regarding Direct Vmentioning

confidence: 99%

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Kim¹,

Ekstrom

Tandon³

2016

Neurobiology of Learning and Memory

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A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. that disrupting frontal or parietal regions also impairs memory performance, suggesting that these regions also play necessary roles in declarative memory. On the other hand, a handful of both invasive and non-invasive studies have also suggested modest improvements in memory performance following stimulation. These studies typically target brain regions connected to the hippocampus or other memory "hubs," which may affect endogenous activity in connected areas like the hippocampus, suggesting that to augment declarative memory, altering the broader endogenous memory network activity is critical. Together, studies reporting memory improvements / impairments are consistent with the idea that a network of distinct brain "hubs" may be crucial for successful memory encoding and retrieval rather than a single primary hub such as the hippocampus. Thus, it is important to consider neurostimulation from the network perspective, rather than from a purely localizationalist viewpoint. We conclude by proposing a novel approach to neurostimulation for declarative memory modulation that aims to facilitate interactions between multiple brain "nodes" underlying memory rather than considering individual brain regions in isolation.

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“…Future correlation studies between the MEP and the TEP component changes at the single trial level (Mäki and Ilmoniemi, 2010) or between the MEPs and the weighted TEP (Vernet et al, 2013) are necessary to understand the relationship between the tDCS-induced effects on the corticospinal and the cortical excitability and their measures.…”

Section: Correlation Between Corticospinal Excitability and Cortical mentioning

confidence: 99%

Excitability modulation of the motor system induced by transcranial direct current stimulation: A multimodal approach

2013

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Anodal and cathodal transcranial direct current stimulations (tDCS) are both established techniques to induce cortical excitability changes. Typically, in the human motor system, such cortical modulations are inferred through changes in the amplitude of the motor evoked potentials (MEPs). However, it is now possible to directly evaluate tDCS-induced changes at the cortical level by recording the transcranial magnetic stimulation evoked potentials (TEPs) using electroencephalography (EEG). The present study investigated the modulation induced by the tDCS on the motor system. The study evaluates changes in the MEPs, in the amplitude and distribution of the TEPs, in resting state oscillatory brain activity and in behavioral performance in a simple manual response task. Both the short-and long-term tDCS effects were investigated by evaluating their time course at~0 and 30 min after tDCS. Anodal tDCS over the left primary motor cortex (M1) induced an enhancement of corticospinal excitability, whereas cathodal stimulation produced a reduction. These changes in excitability were indexed by changes in MEP amplitude. More interestingly, tDCS modulated the cortical reactivity, which is the neuronal activity evoked by TMS, in a polarity-dependent and site-specific manner. Cortical reactivity increased after anodal stimulation over the left M1, whereas it decreased with cathodal stimulation. These effects were partially present also at long term evaluation. No polarity-specific effect was found either on behavioral measures or on oscillatory brain activity. The latter showed a general increase in the power density of low frequency oscillations (theta and alpha) at both stimulation polarities. Our results suggest that tDCS is able to modulate motor cortical reactivity in a polarity-specific manner, inducing a complex pattern of direct and indirect cortical activations or inhibitions of the motor system-related network, which might be related to changes in synaptic efficacy of the motor cortex.

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Insights on the neural basis of motor plasticity induced by theta burst stimulation from TMS–EEG

Cited by 85 publications

References 39 publications

Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry

Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Excitability modulation of the motor system induced by transcranial direct current stimulation: A multimodal approach

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