Instabilité des microsatellites : un nouveau mécanisme de carcinogenèse associé à l’immunodépression dans les lymphomes non hodgkiniens chez l’homme

Borie, Claire; Raphaël, Martine; Hamelin, Richard; Duval, Alex

doi:10.1051/medsci/2004206-7641

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They can be inherited. However, they are in most cases of sporadic occurrence, representing about 15% of cases of colon cancer, stomach, pancreas or endometrial cancer (Borie et al, 2004). Previous MSI reports on sporadic breast cancers are probably incompatible with some studies which have noted an absence or scarcity of microsatellite instability in breast tumors (Hye-Jung et al, 1993;Peltomaki et al, 1993;Wooster et al, 1994), while others studies have reported a remarkably high frequency of MSI in breast cancer (Kim et al, 1994;Yee et al, 1994;Aldaz et al, 1995;Contegiacomo et al, 1995;Karnik et al, 1995;Shaw et al, 1996;Toyama et al, 1996;Toyama et al, 1996b;Paulson et al, 1996;Sourvinos et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological and survival significance of BAT-25 and BAT-26 instability in breast cancer among Senegalese patients

Mbaye

Dem

et al. 2015

J. Cancer Res. Exp. Oncol.

View full text Add to dashboard Cite

In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. The primary aim of this study is to evaluate the clinicopathological and survival significance of BAT-25 and BAT-26 instability, in 60 patients with breast cancer. Polymerase chain reaction was used to amplify the following microsatellite repeat loci BAT-25 and BAT-26. Medical records were studied in order to determine clinical data of BAT-25 and BAT-26, analysis was carried out. 60.71% of cancer tissues analyzed were found to be unstable for both markers.BAT-26 instability has an impact on the age (Od: 15.47; CI 1.08-974; 19, P: 0.020) and survival (P: 0.0342) of patients. BAT-26 which has a poly A sequence, can be considered alone as a good marker for the detection of MSI tumors in breast cancer.

show abstract