Instant diagnosis of spontaneous bacterial peritonitis using leukocyte esterase reagent strips: Nephur‐Test<sup>®</sup> vs. MultistixSG<sup>®</sup>

Sapey, Thierry; Kabissa, Denis; Fort, Eric; Laurin, Christine; Mendler, Michel

doi:10.1111/j.1478-3231.2005.01086.x

Cited by 49 publications

(56 citation statements)

References 16 publications

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“…The sensitivity and specificity of the reagent strip (Aution sticks®; A. Menarini Diagnostics, Firenze, Italy) were 96% and 89%, respectively [26]. Other studies have been carried out in order to confirm the performance of different reagent strips in SBP diagnosis in inpatient and outpatient settings reaching similar results [26][27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 69%

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Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?

Ribeiro¹,

Kondo²,

Amaral³

et al. 2007

Braz J Infect Dis

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) for the rapid bedside diagnosis of spontaneous bacterial peritonitis. The mean age 54 ± 12 years, there was a predominance of males (eighty-two patients, 77%), and alcohol was the most frequent etiology (43%). Forty-four percent of patients were classified as Child B and fifty-one as Child C (51%). Abdominal paracentesis was performed both in outpatient and inpatient settings and the Multistix 10SG® ® ® ® ® was tested. Eleven cases of spontaneous bacterial peritonitis were identified by means of polymorphonuclear count. If we considered the positive Multistix 10SG® ® ® ® ® result of 3 or more, the sensitivity, specificity, positive and negative predictive value were respectively 71%, 99%, 91% and 98%. With a positive reagent strip result taken as grade 2 (traces) or more, sensitivity was 86% and specificity was 96% with positive and negative predictive values of 60% and 99%, respectively. Diagnostic accuracy was 95%. We concluded that the use of a urine reagent dipstick (Multistix 10SG® ® ® ® ®) could be considered a quick, easy and cheap method for ascitic fluid cellularity determination in SBP diagnosis.

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Section: Discussionmentioning

confidence: 69%

“…Recently, Sapey et al showed that different brands can achieve different accuracy in the diagnosis of SBP [33]. The authors compare two different reagent strips (Multistix SG x Nephur-Test) finding that the Nephur-Test seems to out-perform Multistix SG.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?

Ribeiro¹,

Kondo²,

Amaral³

et al. 2007

Braz J Infect Dis

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“…The first study [36] , published in 2002, involved 72 cirrhotic patients, nine of whom had SBP, reported a sensitivity and a specificity of 100% for the urinary strips in the diagnosis of SBP. After this successful result, in the following years a number of reports [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] evaluated the urine strip test for the diagnosis of SBP (Table 2). These studies reported promising and encouraging results, with the sensitivity of urinary strips for the diagnosis of SBP ranging between 85% and 100% and the specificity between 90 and 100%.…”

Section: The Determination Of Pmn Cells In the Ascitic Fluidmentioning

confidence: 99%

Ascitic fluid analysis for diagnosis and monitoring of spontaneous bacterial peritonitis

Riggio¹,

Angeloni²

2009

WJG

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Polymorphonuclear (PMN) cell count in the ascitic fluid is essential for the diagnosis and management of spontaneous bacterial peritonitis (SBP). To date, PMN cell count is routinely performed by traditional manual counting. However, this method is time-consuming, costly, and not always timely available. Therefore, considerable efforts have been made in recent years to develop an alternative test for a more rapid diagnosis and monitoring of SBP. The use of urinary reagent strips was proposed to achieve an "instant" bedside diagnosis of SBP. A series of reports evaluated the urine strip test for SBP diagnosis and reported promising results. However, a recent large multicenter study revealed a surprising lack of diagnostic efficacy of the urine screening test for SBP diagnosis. Another method, more recently proposed as an alternative to the manual PMN count, is the measurement of lactoferrin in ascitic fluid, but the data available on the diagnostic value of this test are limited to a single study. However, both urinary reagent strips and ascitic lactoferrin tests are qualitative methods and need, therefore, to be further confirmed by standard cytology of the ascitic fluid. To date, the only quantitative method proposed as a valid alternative to manual PMN counting is automated blood cell counters, commonly used in all laboratories for blood cell counting. Data available in the literature on the diagnostic performance of this method are limited but very promising, and this tool seems to have the potential to replace the manual counting method.

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“…Compared with the manual PMN count ('gold standard'), LERS were found to have sensitivity ranging from 45 to 100%, specificity ranging from 81 to 100%, PPV value ranging from 42 to 100% and NPV ranging from 87 to 100%. [4][5][6][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Similarly, the published studies in which Multistix reagent strips were used have also shown widely variable test results (Table 3). 4,[12][13][14][17][18][19][20]24 In an only study from India, authors have shown the Multistix strip's sensitivity, specificity, PPV and NPV of 97%, 89%, 87% and 83% respectively using a cut-off of grade 2.…”

Section: Uriscanmentioning

confidence: 99%

Multistix 10 SG Leukocyte Esterage Dipstick Testing in Rapid Bedside Diagnosis of Spontaneous Bacterial Peritonitis: A Prospective Study

Jha

Kumawat

Bolya

et al. 2012

Journal of Clinical and Experimental Hepatology

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Background and Aims: Spontaneous bacterial peritonitis (SBP) requires rapid diagnosis and the initiation of antibiotics. Diagnosis of SBP is usually based on cytobacteriological examination of ascitic fluid. These tests require good laboratory facilities and reporting time of few hours to 1-2 day. However, the 24 h laboratory facilities not widely available in country like India. We evaluated the diagnostic utility of reagent strip (Multistix 10 SG Ò ) for

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Instant diagnosis of spontaneous bacterial peritonitis using leukocyte esterase reagent strips: Nephur‐Test^® vs. MultistixSG^®

Cited by 49 publications

References 16 publications

Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?

Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?

Ascitic fluid analysis for diagnosis and monitoring of spontaneous bacterial peritonitis

Multistix 10 SG Leukocyte Esterage Dipstick Testing in Rapid Bedside Diagnosis of Spontaneous Bacterial Peritonitis: A Prospective Study

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Instant diagnosis of spontaneous bacterial peritonitis using leukocyte esterase reagent strips: Nephur‐Test® vs. MultistixSG®

Cited by 49 publications

References 16 publications

Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?

Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?

Ascitic fluid analysis for diagnosis and monitoring of spontaneous bacterial peritonitis

Multistix 10 SG Leukocyte Esterage Dipstick Testing in Rapid Bedside Diagnosis of Spontaneous Bacterial Peritonitis: A Prospective Study

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Instant diagnosis of spontaneous bacterial peritonitis using leukocyte esterase reagent strips: Nephur‐Test^® vs. MultistixSG^®