Instrument to detect syncope and the onset of shock

McAdams, Daniel R.; Kolodziejski, Noah J.; Stapels, Christopher J.; Fernandez, Daniel E.; Podolsky, Matthew J.; Farkas, Dana; Christian, James F.; Joyner, Michael J.; Johnson, Christopher P.; Paradis, Norman A.

doi:10.1117/12.2212803

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…1(a). The construction details can be found in our previous reports 22 , 23 . The core DCS components that enabled this miniaturization were a relatively inexpensive and small 785-nm LD (LD785-SH300, Thorlabs, Newton, New Jersey) and a custom, hardware-based time tagger using a programmable system-on-a-chip (PSoC) for implementing a software correlator.…”

Section: Methodsmentioning

confidence: 99%

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

et al. 2017

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In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels. Further studies featuring long-term monitoring, arterial failure simulations, and venous failure simulations were performed on flaps that had undergone an anastomosis procedure (n=4). Additionally, benchtop verification of the DCS system was performed on liquid flow phantoms. Data revealed relationships between diffuse optical measures and state of occlusion as well as the ability to detect arterial and venous compromise. The compact construction of the device, along with its noninvasive and quantitative nature, would make this technology suitable for clinical translation.

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Section: Methodsmentioning

confidence: 99%

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

et al. 2017

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“…In fact, there is no noticeable, consistent difference between the two. Notably, it also happens in previous, basic phantoms with a single, large tube running through them 6,7 . This suggests that unlike Doppler-based techniques, DCS is insensitive to the direction of the flow that it is measuring.…”

Section: Resultsmentioning

confidence: 70%

“…Autocorrelation plots were taken using a multi-channel diffuse correlation spectroscopy (DCS) instrument 7 developed at RMD, Inc. for both the twisting and straight sections of the phantom. Three 30 second runs were completed for each section with the syringe pump pushing Intralipid through the phantom at 0, 0.2, 10, and 20 ml/min, as well as water at 20 ml/min and Intralipid pushed through by hand at about 30 ml/min.…”

Section: Verification Methodsmentioning

confidence: 99%

A capillary-mimicking optical tissue phantom for diffuse correlation spectroscopy

et al. 2017

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Optical tissue phantoms are necessary for instrument benchmarking and providing a consistent baseline for experiments in various fields of tissue spectroscopy, including diffuse correlation spectroscopy (DCS). To provide the most useful comparisons, a phantom would ideally mimic tissue as closely as possible, including the geometry of static and dynamic scatterers. A branching design that keeps the capillary cross section constant ensures that the same flow velocity is found throughout the phantom while allowing for single input and output fittings to feed all of the capillaries simultaneously. The direction of each capillary is randomized every few millimeters by randomly allocating 2 by 2 “twisting” squares within each layer. These squares swap the locations of four adjacent artificial capillaries either clockwise or counterclockwise. Numerical simulations were used to verify the random walk-like behavior of the capillary paths resulting from this pattern. This is a step toward replicating the randomly varying directionality of actual capillaries. This design was verified by taking DCS measurements at different flow rates of Intralipid through the phantom, demonstrating the effect of the flow rate on the characteristic decay time of the autocorrelation.

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“…In experimental models of decreased cardiac output due to simulated hypovolemia (lower body negative pressure) indicators of peripheral perfusion indicate hypoperfusion of the skin (6)(7)(8). In experimental models of decreases in cardiac output (CO) either due to tamponade or endotoxin infusion, sublingual microcirculatory perfusion decreases while its restored following resuscitation (removal of tamponade and fluids) (9).…”

Section: Basic (Patho)physiologic Principlesmentioning

confidence: 99%

Can Peripheral Skin Perfusion Be Used to Assess Organ Perfusion and Guide Resuscitation Interventions?

Bakker

Hernández

2020

Front. Med.

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Although the definition of septic shock is straightforward, the physiological response to inadequate hemodynamics in patients with septic shock is variable. Therefore, the clinical recognition is limited not only by the patient's response but also by the clinical parameters we can use at the bedside. In this short overview we will argue that the state of the peripheral perfusion can help to identify and to treat patients with septic shock.

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Instrument to detect syncope and the onset of shock

Cited by 5 publications

References 25 publications

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

A capillary-mimicking optical tissue phantom for diffuse correlation spectroscopy

Can Peripheral Skin Perfusion Be Used to Assess Organ Perfusion and Guide Resuscitation Interventions?

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