Instrumented posterolateral lumbar fusion using coralline hydroxyapatite with or without demineralized bone matrix, as an adjunct to autologous bone

Thalgott, John S.; Giuffre, James M.; Fritts, Kay; Timlin, Marcus; Klézl, Zdeněk

doi:10.1016/s1529-9430(01)00011-0

Cited by 77 publications

(31 citation statements)

References 34 publications

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“…Its osteoconductive function and qualification as a graft extender were shown in our previous clinical studies compared to those of the autogenous iliac bone graft in human posterolateral fusion of lumbar spine, which is consistent with results from other studies using synthetic hydroxyapatite in posterolateral fusion [13][14][15][16]. However, in interbody fusion, there are contradictory reports on the efficacy of synthetic hydroxyapatite as a graft extender [15][16][17].…”

Section: Introductionsupporting

confidence: 89%

The efficacy of porous hydroxyapatite bone chip as an extender of local bone graft in posterior lumbar interbody fusion

et al. 2011

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Objective To evaluate whether a synthetic bone chip made of porous hydroxyapatite can effectively extend local decompressed bone graft in instrumented posterior lumbar interbody fusion (PLIF). Methods 130 patients, 165 segments, who had undergone PLIF with cages and instrumentation for single or double level due to degenerative conditions, were investigated retrospectively by independent blinded observer. According to the material of graft, patients were divided into three groups. HA group (19 patients, 25 segments): with hydroxyapatite bone chip in addition to autologous local decompressed bone, IBG group (25 patients, 28 segments): with autologous iliac crest bone graft in addition to local decompressed bone and LB group (86 patients, 112 segments): with local decompressed bone only. Radiologic and clinical outcome were compared among groups and postoperative complications, transfusion, time and cost of operation and duration of hospitalization were also investigated. Results Radiologic fusion rate and clinical outcome were not different. Economic cost, transfusion and hospital stay were also similar. But operation time was significantly longer in IBG group than in other groups. There were no lasting complications associated with HA and LB group with contrast to five cases with persisting donor site pain in IBG group. Conclusion Porous hydroxyapatite bone chip is a useful bone graft extender in PLIF when used in conjunction with local decompressed bone.

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Section: Introductionsupporting

confidence: 89%

The efficacy of porous hydroxyapatite bone chip as an extender of local bone graft in posterior lumbar interbody fusion

et al. 2011

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“…[16][17][18][19] In clinical contexts such as revision arthroplasty, spinal fusion, nonunion fractures, or dental augmentation, the use of DBM as a graft substitute or extender has already proven to be successful. [20][21][22][23] Although reports suggest that DBM in particulate form is a useful bone graft with osteoconductive and osteoinductive properties, limitations to its clinical utility may be caused by the tendency of the powder to migrate from bleeding graft sites and difficulty in handling the material. The commonly used morselized DBM contains bone fragments that do not exceed 500 mm in diameter.…”

Section: Introductionmentioning

confidence: 99%

Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix

et al. 2006

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Injectable hydrogel and porous sponge formulations of Carbylan TM -GSX, a crosslinked synthetic extracellular matrix (ECM), were used to deliver human demineralized bone matrix (DBM) in a rat femoral defect model. A cortical, full-thickness 5-mm defect was created in two femurs of each rat. Six rats were assigned to each of five experimental groups (thus, 12 defects per group). The defects were either untreated or filled with Carbylan TM -GSX hydrogel or sponges with or without 20% (w/v) DBM. Radiographs were obtained on day 1 and at weeks 2, 4, 6, and 8 postsurgery of each femur. Animals were sacrificed at week 8 postsurgery and each femur was fixed, embedded, sectioned, and processed for Masson's Trichrome staining. The bone defects were measured from radiographs and the fraction of bone healing was calculated. The average fractions of bone healing for each group were statistically different among all groups, and all treatment groups were significantly better than the control group. The Carbylan TM -GSX sponge with DBM was superior to the sponge without DBM and to the hydrogel with DBM. Histology showed that defects treated with the Carbylan TM -GSX sponge plus DBM were completely filled with newly generated bone tissue with a thickness comparable to native bone. Carbylan TM -GSX sponge was an optimal delivery vehicle for human DBM to accelerate bone healing. ß

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“…Thalgott et al [42] compared CHA and demineralized bone matrix as an adjunct to autologous bone, and showed a 92.5% fusion rate. CHA is an effective bone graft extender in difficult-to-fuse patients when combined with rigid instrumentation.…”

Section: Discussionmentioning

confidence: 99%

“…Biomechanical studies in animals [5,27,42] compared spinal arthrodesis using interconnected HA alone or mixed with bone as graft material and reduced spinal segmental motion. Baramki et al [5], however, noted that HA was not as effective as autologous bone graft material in achieving spinal arthrodesis in animals.…”

Section: Discussionmentioning

confidence: 99%

Correlative radiological, self-assessment and clinical analysis of evolution in instrumented dorsal and lateral fusion for degenerative lumbar spine disease. Autograft versus coralline hydroxyapatite

et al. 2005

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Instrumented posterolateral lumbar fusion using coralline hydroxyapatite with or without demineralized bone matrix, as an adjunct to autologous bone

Cited by 77 publications

References 34 publications

The efficacy of porous hydroxyapatite bone chip as an extender of local bone graft in posterior lumbar interbody fusion

The efficacy of porous hydroxyapatite bone chip as an extender of local bone graft in posterior lumbar interbody fusion

Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix

Correlative radiological, self-assessment and clinical analysis of evolution in instrumented dorsal and lateral fusion for degenerative lumbar spine disease. Autograft versus coralline hydroxyapatite

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