Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification

Gehrmann, Sandra; Bunjes, Heike

doi:10.1016/j.cej.2015.09.022

Cited by 20 publications

(18 citation statements)

References 21 publications

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“…Bunjes et al prepared nanoemulsions by PME with droplet size lower or around 200 nm with narrow size distribution with polymeric membranes and SPG membranes for volumes up to 10 mL. [10,14,15]. In a previous work, we reported the production of O/W nanoemulsions by PME and SPG membranes at high flowrate and relatively large volumes up to 500 mL [16].…”

Section: Introductionmentioning

confidence: 87%

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Alliod

Messager

Fessi

et al. 2019

Chemical Engineering Research and Design

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Oil-in-water and water-in-oil nanoemulsions are interesting carriers for respectively oil soluble and water soluble actives. In this study, oil-in-water (O/W) and water-in-oil (W/O) nanoemulsions were prepared by premix membrane emulsification. A coarse emulsion (premix) was injected thanks to a high pressure pump through a Shirasu Porous Glass (SPG) membrane with pore size of 0.5 µm in order to reduce and homogenize the droplet size. The effect of viscosities on the pressure and droplet size was investigated: the water phase viscosity by increasing glycerol concentration, the oil phase viscosity with mineral oils of different viscosities and the overall emulsion viscosity by increasing the dispersed phase content of the emulsion. The pressure required to break up the droplets inside the membrane pores ∆P dis did not depend on viscosities, while the pressures generated by the flows through the pipe ∆P pipe and the membrane ∆P f low were proportional to the viscosity of the overall emulsion. W/O nanoemulsions were more difficult to produce and to characterize but thanks to the original setup working at pressures up to 65 bar and high flowrates, W/O mineral oil nanoemulsions were produced with mean droplets size around 600 nm and flow rate of 50 mL/min.

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Section: Introductionmentioning

confidence: 87%

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Alliod

Messager

Fessi

et al. 2019

Chemical Engineering Research and Design

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“…For the premix membrane emulsification, an instrumented small-scale extruder, developed by Gehrmann et al [19] was used. Its components are a high pressure computer controlled syringe pump (neMESYS UserInterface software, version 2.6.0.4.…”

Section: Instrumented Small-scale Extrudermentioning

confidence: 99%

Investigation of Nanoporous Superalloy Membranes for the Production of Nanoemulsions

Kohnke

Finke

Kwade

et al. 2018

Metals

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Premix membrane emulsification is a gentle process for producing nanoemulsions, i.e., for pharmaceutical purposes. The operating time of common membranes is short today, because of their fragility, membrane fouling and poor cleanability. In contrast, superalloy membranes are cleansable because of their high mechanical strength as well as high chemical and thermal resistances and therefore, could achieve clearly longer operating times. Their usability for premix membrane emulsification is investigated in this study. Different flow rates of the premix emulsion were tested up to 21 cycles with a small-scale extruder, three different nanoporous superalloy membrane structures have been tested in comparison to a common polymer membrane. Varying the two-phase-structure (γ-and γ-phase) of superalloy bulk material through thermal or thermo-mechanical treatments and chemical extraction of either one of the phases, different membrane microstructures could be obtained. These membranes differ in pore size, pore structure, and porosity, resulting in different flow resistances, droplet sizes and droplet size distributions in the investigated premix membrane emulsification process. Emulsions with droplet sizes in the desired range of 100 to 500 nm and with acceptable droplet size distributions were achieved. Data display an improved process stability for superalloy membranes, however, special attention needs to be paid towards narrow droplet size distributions.

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“…For the production of nanoemulsions, PME is of great interest. Bunjes et al prepared nanoemulsions by PME with droplet sizes lower or around 200 nm with a narrow size distribution [18,19,20]). This result was explained by the high pore tortuosity and thickness of the Shirasu Porous Glass (SPG) membranes which are the most commonly used membranes for emulsification.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Using these SPG membranes and PME, Bunjes and Joseph produced a few milliliters of nanoemulsion [18,19,21]. The production of nanoemulsions by membrane emulsification remains a challenging undertaking [18] especially for large volumes at high flowrates. Hitherto, this process has been used to homogenize small amounts of emulsion, but a recent publication by Alliod et al [22] proposed a novel approach which allowed the homogenization of 500 mL of coarse emulsion into a nanoemulsion by running it through membranes with average pore sizes at a minimum of 0.2 µm whilst keeping pressure under 60 bars.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Three Processes for Parenteral Nanoemulsion Production: Ultrasounds, Microfluidizer, and Premix Membrane Emulsification

Alliod

Almouazen

Nemer

et al. 2019

Journal of Pharmaceutical Sciences

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Nanoemulsions are of great interest for pharmaceutical applications, including parenteral dosage forms. However, their production is still limited and requires more efficient and adaptive technologies. The more common systems are high-shear homogenization like microfludizers (MF) at industrial scale and ultrasounds at research scale, both based on high energy limiting their application for sensitive drugs. Recently, a process based on premix membrane emulsification (PME) was developed to produce nanoemulsions. These three processes have been compared for the production of a model parenteral nanoemulsion containing all-transretinoic acid, a thermolabile molecule which is used in the treatment of acute promyelocytic leukemia in a parenteral form. Droplet size and active integrity were studied because of their major interest for efficacy and safety assessment. Regarding droplet size, PME produced monodispersed droplets of 335 nm compared to the other processes which produced nanoemulsions of around 150 nm but with the presence of micron size droplets detected by laser diffraction and optical microscopy. No real difference between the three processes was observed on active degradation during emulsifcation. However, regarding stability, especially at 40 o C nanoemulsions obtained with the microfluidizer showed a greater molecule degradation and unstable nanoemulsion with a 4 times droplet size increase under stress conditions.

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Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification

Cited by 20 publications

References 21 publications

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Investigation of Nanoporous Superalloy Membranes for the Production of Nanoemulsions

Comparison of Three Processes for Parenteral Nanoemulsion Production: Ultrasounds, Microfluidizer, and Premix Membrane Emulsification

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