Insufficient Sleep, Electroencephalogram Activation, and Seizure Risk: Re‐Evaluating the Evidence

Rossi, Kyle C.; Joe, Jalyoung; Makhija, Monica; Goldenholz, Daniel M.

doi:10.1002/ana.25710

Cited by 28 publications

(33 citation statements)

References 66 publications

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“…Other factors widely accepted as seizure precipitants based on patient reports and clinical experience lack supportive statistical evidence. For example, sleep deprivation is commonly deemed a strong seizure precipitant, but a recent systematic review revealed the paucity of evidence for this association 45 …”

Section: External‐endogenous Borderlandmentioning

confidence: 99%

Cues for seizure timing

et al. 2020

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The cyclical organization of seizures in epilepsy has been described since antiquity. However, historical explanations for seizure cycles—based on celestial, hormonal, and environmental factors—have only recently become testable with the advent of chronic electroencephalography (cEEG) and modern statistical techniques. Here, factors purported over millennia to influence seizure timing are viewed through a contemporary lens. We discuss the emerging concept that seizures are organized over multiple timescales, each involving differential influences of external and endogenous rhythm generators. Leveraging large cEEG datasets and circular statistics appropriate for cyclical phenomena, we present new evidence for circadian (day‐night), multidien (multi‐day), and circannual (about‐yearly) variation in seizure activity. Modulation of seizure timing by multiscale temporal variables has implications for diagnosis and therapy in clinical epilepsy. Uncovering the mechanistic basis for seizure cycles, particularly the factors that govern multidien periodicity, will be a major focus of future work.

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Section: External‐endogenous Borderlandmentioning

confidence: 99%

Cues for seizure timing

et al. 2020

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“…As opposed to IEDs, there is a controversy on whether SD exacerbates seizures in humans. 49 In the Kv1.1 À/À mouse model, SD indeed exacerbated seizure frequency but also hastened mortality. 50 In the same model, sleep progressively declined prior to mortality, 51 suggesting that SD may be a factor in causing disease progression and is relevant for epilepsyrelated mortality.…”

Section: Mechanisms Of Sd-associated Seizure Exacerbationmentioning

confidence: 97%

Untangling a Web: Basic Mechanisms of the Complex Interactions Between Sleep, Circadian Rhythms, and Epilepsy

Maganti

Jones

2021

Epilepsy Curr

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Seizures have sleep–wake and circadian patterns in various epilepsies and, in turn, disrupt sleep and circadian rhythms. The resultant sleep deprivation (SD) is an exacerbating factor for seizures that sets up a vicious cycle that can potentially lead to disease progression and even to epilepsy-related mortality. A variety of cellular or network electrophysiological changes and changes in expression of clock-controlled genes or other transcription factors underlie sleep–wake and circadian distribution of seizures, as well as the disruptions seen in both. A broad understanding of these mechanisms may help in designing better treatments to prevent SD-induced seizure exacerbation, disrupt the vicious cycle of disease progression, and reduce epilepsy-related mortality.

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“…One study has even shown that two-channel subscalp EEG is sufficient to do robust sleep staging. 71,72 | 1813 DUUN-HENRIKSEN Et al.…”

Section: Using Subscalp Eeg In the Futurementioning

confidence: 99%

“…Furthermore, as a relationship between sleep quality/duration and seizure risk has been suggested, the ability to record objective sleep quality and seizures is critical to understanding whether strategies to improve sleep can help seizure control. One study has even shown that two‐channel subscalp EEG is sufficient to do robust sleep staging 71,72 …”

Section: Utility Of Subscalp Eeg Recordingmentioning

confidence: 99%