Insuffisance rénale secondaire à une intoxication au paracétamol : à propos de 3 cas

Vaillant, J. Le; Pellerin, L.; Brouard, J.; Eckart, P.

doi:10.1016/j.arcped.2013.03.027

Cited by 10 publications

(5 citation statements)

References 15 publications

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“…In our observation, we diagnosed renal failure and hepatocellular insufficiency at the same time, contrary to a similar study where renal failure appeared after the improvement of the hepatic balance, this chronology being an argument to confirm the diagnosis of acute tubular necrosis secondary to the intake of paracetamol and not in favour of a hepatorenal syndrome [11].…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

Coulibaly¹,

Samaké²,

Samba³

et al. 2022

OJNeph

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Section: Discussioncontrasting

confidence: 99%

“…In an observational study of VMI with paracetamol in 3 adolescent girls, only one had oliguria with onset of acidosis, but none required extrarenal purification [11].…”

Section: Discussionmentioning

confidence: 99%

Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

Coulibaly¹,

Samaké²,

Samba³

et al. 2022

OJNeph

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“…4,6,9 However, once this detoxification process becomes saturated because of the following reasons: (i) induction or stabilization of CYP enzymes that form NAPQI, (ii) depletion of GSH conjugation pathway, or (iii) a combination of these two processes, NAPQI may accumulate and covalently bind to hepatic and renal tubular cell proteins and cause cell necrosis. 4,6,10 Thus, simultaneous evaluation of a combination of metabolic enzyme pathways under different physiological and pathological conditions will help in elucidating potential bioactivation mechanisms related to APAP toxicity.…”

mentioning

confidence: 99%

Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children

Jiang

Zhao

Barrett

et al. 2013

CPT Pharmacom & Syst Pharma

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Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that undergoes extensive phase I and II metabolism. To better understand the kinetics of this process and to characterize the dynamic changes in metabolism and pharmacokinetics (PK) between children and adults, we developed a physiologically based PK (PBPK) model for APAP integrating in silico, in vitro, and in vivo PK data into a single model. The model was developed and qualified for adults and subsequently expanded for application in children by accounting for maturational changes from birth. Once developed and qualified, it was able to predict clinical PK data in neonates (0–28 days), infants (29 days to <2 years), children (2 to <12 years), and adolescents (12–17 years) following intravenous and orally administered APAP. This approach represents a general strategy for projecting drug exposure in children, in the absence of pediatric PK information, using previous drug- and system-specific information of adults and children through PBPK modeling.

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“…in 2008, for whom this substance was most frequently used, in all ages combined [22]. Paracetamol over dose of this drug can cause liver and kidneys disorders [23,24]. These findings are likely to be associated with its availability.…”

Section: Discussionmentioning

confidence: 99%

Deliberate self-poisoning with drugs among adolescents in Morocco

et al. 2021

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Introduction: Suicide is a serious public health problem and one of the leading causes of adolescent death in the world. The aim of this study is to determine the epidemiological profile of suicidal poisoning with drugs among adolescents in Morocco. Methods: This is a retrospective study of deliberate self-poisoning cases, reported to the Moroccan Poison Control Center between 1980 and 2014. Results: A total of 3,856 cases of suicidal poisoning among adolescents 15 to 19 years old were recorded, with 13 cases of successful suicide and 41 repeated suicide attempts. The average age of the patients was 15.5 years. According to the results, 84.7% were female with a female-male ratio of 5.5. The majority of cases occurred at home (97.8%). The signs and symptoms presented by the patients were varied, depending on the amount of drug ingested and the delay before treatment. Conclusion: Suicide and suicide attempts in children and adolescents continue to be a major public health problem, and topical research and surveys have clearly highlighted suicide as one of the commonest causes of death among young people.

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Insuffisance rénale secondaire à une intoxication au paracétamol : à propos de 3 cas

Cited by 10 publications

References 15 publications

Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children

Deliberate self-poisoning with drugs among adolescents in Morocco

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