Insulin-like growth factor binding protein 2 null mice (Igfbp2−/−) are protected against trabecular bone loss after vertical sleeve gastrectomy

Harris, Benjamin T; Le, Phuong; Martins, Janaina da Silva; Alabdulaaly, Lama; Baron, Roland; Bouxsein, Mary L.; Rosen, Clifford J.; Pletch, Alison

doi:10.1007/s00464-022-09069-1

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Mstn (myostatin), a myokine that is produced and released by muscles throughout the body, also acts as a negative regulator of skeletal‐muscle growth [40], and animals either lacking Mstn or treated with an Mstn inhibitor have significantly more muscle mass than controls [41]. Mice with Igfbp2 knockout, which inhibits bone development, are protected against trabecular bone loss [42]. Many of these proteins contribute to a variety of other biological functions, and it remains unclear why changes in their serum levels occur in mice with gravity unloading exposure.…”

Section: Resultsmentioning

confidence: 99%

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Kimura,

Nakai,

Ino

et al. 2024

Proteomics

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Physical inactivity associated with gravity unloading, such as microgravity during spaceflight and hindlimb unloading (HU), can cause various physiological changes. In this study, we attempted to identify serum proteins whose levels fluctuated in response to gravity unloading. First, we quantitatively assessed changes in the serum proteome profiles of spaceflight mice using mass spectrometry with data‐independent acquisition. The serum levels of several proteins involved in the responses to estrogen and glucocorticoid, blood vessel maturation, osteoblast differentiation, and ossification were changed by microgravity exposure. Furthermore, a collective evaluation of serum proteomic data from spaceflight and HU mice identified 30 serum proteins, including Mmp2, Igfbp2, Tnc, Cdh5, and Pmel, whose levels varied to a similar extent in both gravity unloading models. These changes in serum levels could be involved in the physiological changes induced by gravity unloading. A collective evaluation of serum, femur, and soleus muscle proteome data of spaceflight mice also showed 24 serum proteins, including Igfbp5, Igfbp3, and Postn, whose levels could be associated with biological changes induced by microgravity. This study examined serum proteome profiles in response to gravity unloading, and may help deepen our understanding of microgravity adaptation mechanisms during prolonged spaceflight missions.

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Section: Resultsmentioning

confidence: 99%

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Kimura,

Nakai,

Ino

et al. 2024

Proteomics

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IGF signaling pathway in bone and cartilage development, homeostasis, and disease

Ruan,

Jin,

Sun

et al. 2024

The FASEB Journal

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The skeleton plays a fundamental role in the maintenance of organ function and daily activities. The insulin‐like growth factor (IGF) family is a group of polypeptide substances with a pronounced role in osteoblast differentiation, bone development, and metabolism. Disturbance of the IGFs and the IGF signaling pathway is inextricably linked with assorted developmental defects, growth irregularities, and jeopardized skeletal structure. Recent findings have illustrated the significance of the action of the IGF signaling pathway via growth factors and receptors and its interactions with dissimilar signaling pathways (Wnt/β‐catenin, BMP, TGF‐β, and Hh/PTH signaling pathways) in promoting the growth, survival, and differentiation of osteoblasts. IGF signaling also exhibits profound influences on cartilage and bone development and skeletal homeostasis via versatile cell–cell interactions in an autocrine, paracrine, and endocrine manner systemically and locally. Our review summarizes the role and regulatory function as well as a potentially integrated gene network of the IGF signaling pathway with other signaling pathways in bone and cartilage development and skeletal homeostasis, which in turn provides an enlightening insight into visualizing bright molecular targets to be eligible for designing effective drugs to handle bone diseases and maladies, such as osteoporosis, osteoarthritis, and dwarfism.

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Insulin-like growth factor binding protein 2 null mice (Igfbp2−/−) are protected against trabecular bone loss after vertical sleeve gastrectomy

Cited by 2 publications

References 45 publications

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

IGF signaling pathway in bone and cartilage development, homeostasis, and disease

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