Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell

Shrivastav, Shailly Varma; Bhardwaj, Apurva; Pathak, Kumar Alok; Shrivastav, Anuraag

doi:10.3389/fcell.2020.00286

Cited by 90 publications

(74 citation statements)

References 163 publications

(216 reference statements)

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“…Consistent with these studies, the expression of decapping enzymes DCP1A and DCP2, and deadenylase CNOT1 and CNOT11 was decreased in YTHDF2 knockdown embryos. CNOT1 is commonly involved in mRNA decay and transcriptional regulation (Paul et al, 2011), and CNOT1 knockout mice died during embryonic development (Shirai et al, 2014). CNOT11 is associated with the N-terminal region of CNOT1 (Bawankar et al, 2013), and its expression was also downregulated in our current study.…”

Section: Discussionsupporting

confidence: 58%

YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat

Deng

Chen

Liu

et al. 2020

Front. Cell Dev. Biol.

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Maternal mRNA clearance is critical for the early embryo development, which is under the tight control of RNA N6-methyladenosine (m 6 A). However, little information is known regarding the maternal mRNA clearance and mechanisms behind it in farm animals. In the present study, 3362 differentially expressed genes (DEGs) were found during the maternal-to-zygotic transition (MZT) and determined as maternal mRNAs in goat. Of which, 1961 was decreased at the 4-cell stage embryos, while 1401 was trigged down-regulation at the 8-cell stage embryos, which were termed as maternally encoded mRNA decay genes and zygotic genome activation (ZGA)-dependent maternal mRNAs, respectively. The expression of m 6 A reader YTHDF2 was increased during goat ZGA, and knockdown of YTHDF2 resulted in decreased blastocyst rate. In the 8-cell stage YTHDF2 knockdown embryos, the M-decay and Z-decay maternal mRNA clearance were impaired. Specifically, the expression of deadenylase (CNOT1 and CNOT11) and decapping enzymes (DCP1A and DCP2) was decreased. In conclusion, we ascertained maternal mRNAs and inferred that maternal mRNA clearance is also ZGA-dependent in goat. We reported that YTHDF2 is vital for goat early embryogenesis as it advances maternal mRNA clearance, which might through the recruitment of deadenylases and mRNA decapping enzymes. This work will be of great value for understanding the stochastic reprogramming events during MZT and achieving better development of goat embryos in vitro.

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Section: Discussionsupporting

confidence: 58%

YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat

Deng

Chen

Liu

et al. 2020

Front. Cell Dev. Biol.

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“…IGF1 and other IGFs bind to IGFBPs with greater affinity than they bind to their receptors (Youssef et al, 2017 ), which allows to protect undifferentiated spermatogonia in the testis against excessive differentiation. Furthermore, recent discoveries have identified that IGFBP-3 plays a dual function of a gatekeeper (induction of apoptosis and cell cycle arrest) and a caretaker (DNA repair through interaction with DNA-PK, induction of autophagy by interaction with GRP78, and the ability to regulate sphingolipids required for the cell survival pathways) through mechanisms independent of IGFs (Varma Shrivastav et al, 2020 ). Taken together, by secreting IGFBPs, MSCs might be able to correct the imbalance of IGF1-mediated regulatory effects between cells within the niche, including Leydig cells, Sertoli cells, and SSCs.…”

Section: Mechanisms Of Msc Participation In Tissue Regenerationmentioning

confidence: 99%

Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration

Sagaradze

Basalova

Efimenko

et al. 2020

Front. Cell Dev. Biol.

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Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell niche, function to maintain tissue homeostasis and regeneration after damage. This demands the existence of specific niche components that can preserve the stem cell pool in injured tissues and restore the microenvironment for their subsequent appropriate functioning. This role may belong to mesenchymal stromal cells (MSCs) due to their resistance to damage signals and potency to be specifically activated in response to tissue injury and promote regeneration by different mechanisms. Increased amount of data indicate that activated MSCs are able to produce factors such as extracellular matrix components, growth factors, extracellular vesicles and organelles, which transiently substitute the regulatory signals from missing niche cells and restrict the injury-induced responses of them. MSCs may recruit functional cells into a niche or differentiate into missing cell components to endow a niche with ability to regulate stem cell fates. They may also promote the dedifferentiation of committed cells to reestablish a pool of functional stem cells after injury. Accumulated evidence indicates the therapeutic promise of MSCs for stimulating tissue regeneration, but the benefits of administered MSCs demonstrated in many injury models are less than expected in clinical studies. This emphasizes the importance of considering the mechanisms of endogenous MSC functioning for the development of effective approaches to their pharmacological activation or mimicking their effects. To achieve this goal, we integrate the current ideas on the contribution of MSCs in restoring the stem cell niches after damage and thereby tissue regeneration.

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“…4 A and B). IGFBP delivers IGFs to the target cells in mammal studies and is essential for cell growth or differentiation (52). The high expression of a receptor of the insulin-like peptide at mature hemocytes in the mosquito suggests that the insulin signaling pathway regulates hemocyte proliferation (53).…”

Section: Expression Of Cell Growth-related Genesmentioning

confidence: 99%

Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

Koiwai

Koyama

Tsuda³

et al. 2021

Preprint

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Crustacean aquaculture is expected to be a major source of fishery commodities in the near future. Hemocytes are key players of the immune system in shrimps; however, their classification, maturation, and differentiation are still under debate. To date, only discrete and inconsistent information on the classification of shrimp hemocytes has been reported, showing that the morphological characteristics are not sufficient to resolve their actual roles. Our present study using single-cell RNA sequencing, revealed nine types of hemocytes of Marsupenaeus japonicus based on their transcriptional profiles. We identified markers of each subpopulation and the differentiation pathways involved in their maturation. We also discovered cell growth factors that might play crucial roles in hemocyte differentiation. Different immune roles among these subpopulations were suggested from the analysis of differentially expressed immune-related genes. These results provide a unified classification of shrimp hemocytes, which improves the understanding of its immune system.

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Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell

Cited by 90 publications

References 163 publications

YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat

YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat

Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration

Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

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