Insulin-like growth factor-binding proteins 2 and 3 are independent predictors of a poor prognosis in patients with dilated cardiomyopathy

Haßfeld, Sabine; Eichhorn, Christina; Stehr, K; Naegele, Herbert; Geier, Christian; Steeg, M. van der; Ranke, Michael B.; Oezcelik, Cemil; Osterziel, Karl Josef

doi:10.1136/hrt.2006.090092

Cited by 17 publications

(15 citation statements)

References 5 publications

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“…32 Additionally, once heart failure is clinically present, it has been shown that low IGFI levels are associated with a worse prognosis. 33,34 These findings suggest that low IGF-I status in adulthood may have implications for the development of premature atherosclerosis or progression of cardiovascular disease. 35 Although epidemiologic studies which have assessed the association between IGF-I levels and cardiovascular disease are inconsistent, it is hypothetically, therefore, possible to partially consider a negative role of the sustained low levels of IGF-1 and ALS in the cardiovascular adverse manifestations commonly seen in untreated hyperthyroidism.…”

Section: Discussionmentioning

confidence: 95%

Changes in Acid Labile Subunit (ALS) and Insulin-Like Growth Factor 1 (IGF-1) Concentration in Hyperthyroidism before and After Medical Treatment: A Prospective Controlled Study

Al-Shoumer¹

2017

EMIJ

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Section: Discussionmentioning

confidence: 95%

Changes in Acid Labile Subunit (ALS) and Insulin-Like Growth Factor 1 (IGF-1) Concentration in Hyperthyroidism before and After Medical Treatment: A Prospective Controlled Study

Al-Shoumer¹

2017

EMIJ

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“…Moreover, it has been demonstrated that IGFBP3, which is a member of the insulin-like growth factor binding protein family, is upregulated in the failing hearts of DCM patients (34,35). Hassfeld et al (36) regard IGFBP3 as an independent predictors of a poor prognosis in patients with DCM. Notably, the results of the present study indicated that upregulated IGFBP3 was related to ‘skeletal system development’ and ‘regulation of cell migration’.…”

Section: Discussionmentioning

confidence: 99%

Identification of the molecular mechanisms underlying dilated cardiomyopathy via bioinformatic analysis of gene expression profiles

Zhuo

et al. 2016

Experimental and Therapeutic Medicine

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In the present study, gene expression profiles of patients with dilated cardiomyopathy (DCM) were re-analyzed with bioinformatics tools to investigate the molecular mechanisms underlying DCM. Gene expression dataset GSE3585 was downloaded from Gene Expression Omnibus, which included seven heart biopsy samples obtained from patients with DCM and five healthy controls. Differential analysis was performed using a Limma package in R to screen for differentially expressed genes (DEGs). Functional enrichment analysis was subsequently conducted for DEGs using the Database for Annotation, Visualization and Integration Discovery. A protein-protein interaction (PPI) network was constructed using information from Search Tool for the Retrieval of Interacting Genes software. A total of 89 DEGs were identified in the patients with DCM, including 67 upregulated and 22 downregulated genes. Functional enrichment analysis demonstrated that the downregulated genes predominantly encoded chromosomal proteins and transport-related proteins, which were significantly associated with the biological processes of ‘nucleosome assembly’, ‘chromatin assembly’, ‘protein-DNA complex assembly’, ‘nucleosome organization’ and ‘DNA packaging’ (H1 histone family member 0, histone cluster 1 H1c, histone cluster 1 H2bd and H2A histone family member Z). The upregulated genes detected in the present study encoded secreted proteins or phosphotransferase, which were associated with biological processes including ‘cell adhesion’ [connective tissue growth factor (CTGF)], ‘skeletal system development’ [CTGF and insulin-like growth factor binding protein 3 (IGFBP3)], ‘muscle organ development’ (SMAD7) and ‘regulation of cell migration’ [SMAD7, IGFBP3 and insulin receptor (INSR)]. Notably, signal transducer and activator of transcription 3, SMAD7, INSR, CTGF, exportin 1, IGFBP3 and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha were hub nodes with the higher degree in the PPI network. Therefore, the results of the present study suggested that DEGs may alter the biological processes of ‘nucleosome formation’, ‘cell adhesion’, ‘skeletal system development’, ‘muscle organ development’ and ‘regulation of cell migration’ in the development of DCM.

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“…A smaller study by Hassfeld et al [11] and a larger study by Jankowska et al [3] reported that low serum levels of IGF-I were associated with increased mortality. As one difference to our investigation the study by Jankowska et al only included men and comprised a larger proportion of younger individuals.…”

Section: P-valuementioning

confidence: 97%

“…Based on this evidence several trials investigating GH treatment in CHF have been conducted [9]. However, there are only very limited reports on the prospective association between endogenous IGF-I levels and the prognosis in CHF patients [3,10,11].…”

Section: Introductionmentioning

confidence: 99%

Plasma insulin-like growth factor I as predictor of progression and all cause mortality in chronic heart failure

Andreassen

Kistorp

Raymond

et al. 2009

Growth Hormone & IGF Research

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Insulin-like growth factor-binding proteins 2 and 3 are independent predictors of a poor prognosis in patients with dilated cardiomyopathy

Cited by 17 publications

References 5 publications

Changes in Acid Labile Subunit (ALS) and Insulin-Like Growth Factor 1 (IGF-1) Concentration in Hyperthyroidism before and After Medical Treatment: A Prospective Controlled Study

Changes in Acid Labile Subunit (ALS) and Insulin-Like Growth Factor 1 (IGF-1) Concentration in Hyperthyroidism before and After Medical Treatment: A Prospective Controlled Study

Identification of the molecular mechanisms underlying dilated cardiomyopathy via bioinformatic analysis of gene expression profiles

Plasma insulin-like growth factor I as predictor of progression and all cause mortality in chronic heart failure

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