Insulin‐Like Growth Factor I Actions on Somatic Growth

Abstract

The sections in this article are: Indirect Evidence that Insulin‐Like Growth Factor I Participates in the Regulation of Somatic Growth Clinical: Correlations Between Growth and Insulin‐Like Growth Factor I Levels in Serum Experimental: Growth Hormone‐Dependent Regulation of Insulin‐Like Growth Factor I m RNA and Protein Expression in Various Tissues and the Autocrine/Paracrine Versus Endocrine Role of Insulin‐Like Growth Factor I Direct Evidence that Insulin‐Like Growth Factor I Promotes Growth Insulin‐Like Growth Factor I as a Growth and Differentiation Factor In Vitro Effects of Insulin‐Like Growth Factor I Administration on Growth In Vivo Transgenic Animals Overexpressing Growth Hormone or Insulin‐Like Growth Factor I Insulin‐Like Growth Factor I and Type 1 Insulin‐Like Growth Factor Receptor Knock‐Out Animals The Somatomedin Hypothesis Revisited

Effect of the <i>IGF-I</i> gene polymorphism on growth, body size, carcass and meat quality traits in Coloured Polish Merino sheep

“…The IGF-I hormone plays a crucial role in the postnatal linear growth of animals (e.g. Yakar et al, 2002;Zapf and Froesch, 1999). In this study an association of the IGF-I gene polymorphism with body size traits and subjective assessment of body muscle and fat class in Coloured Polish Merino sheep was investigated; however, the effects of IGF-I genotypes on these traits were not significant.…”

“…Circulating IGF-I concentration has an impact on fetal and neonatal size and postnatal growth in several species (Baker et al, 1993;Breier et al, 1988;Duclos et al, 1999;Yakar et al, 2002;Zapf and Froesch, 1999) Szewczuk et al (2013) reported effects of two SNPs in the IGF-I gene on body weight in the second month of life in calves and average daily gains in the periods from the first to the second months and from the second to the third months of life and for the whole rearing period. Zhang et al (2008) investigated polymorphism of the IGF-I gene and its association with growth and body size traits in Nanjiang Huang goats.…”

“…IGF-I protein affects longitudinal bone growth by promoting osteoblast division and proliferation. Furthermore, it regulates muscle growth by enhancing myocyte differentiation and multiplication and has an impact on cartilage growth by increasing chondrocyte colony formation (Duclos et al, 1999;Yakar et al, 2002;Zapf and Froesch, 1999). It should be pointed out that there is limited information about effects of the IGF-I gene polymorphism on body size traits, especially in sheep.…”

Detection of Polymorphism at the Insulin Like Growth Factor-I Gene in Mazandaran Native Chicken using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method

“…The IGF1 gene may play important roles in growth of multiple tissues, including muscle cells (myocyte differentiation cell multiplication), cartilage (chondrocyte colony formation, alkaline phosphatase activity) and bone (osteoblast division and proliferation) (Zapf and Froesch, 1999). Intense genetic selection of broilers has successfully increased growth rate and breast muscle percentage.…”

Evaluation of insulin-like growth factor-I gene polymorphism in Egyptian small ruminant breeds

“…IGF-I has an important role in growth of fetal organs and skeletal muscles (Lok et al, 1996). IGF-I is considered as a key factor in animal growth through its effect on longitudinal bone growth, muscle growth and cartilage growth (Duclos et al, 1999;Zapf and Froesch, 1999;Yakar et al, 2002). IGF-1 plays an important role in mammalian fertility through the regulation of many hormones which are critical for reproductive system (Miller and Gore, 2001;Velazquez et al, 2008).…”