Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix

Sablania, Praveen

doi:10.7860/jcdr/2016/17113.7234

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…In a study carried out in India in women diagnosed with SIL, they found that the concentrations of C-peptide, a known marker of endogenous insulin secretion, decreased significantly in the group diagnosed with SIL compared to the control group. However, in this research work, most of the participants with premalignant lesions (96.7%) were not obese since they had a BMI of less than 27 Kg/m 2 [68].…”

Section: Discussionmentioning

confidence: 70%

Association of Serum Concentrations of Testosterone and Insulin with the Degree of Cervical Squamous Intraepithelial Lesions in Cuban Women

Maydelin¹,

Eduardo²,

Cabrera³

et al. 2022

J Cervical Cancer Res

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Cervical squamous intraepithelial lesions (SIL) and cervical cancer (CxCa) develop because of high-risk human papillomavirus (HR-HPV) infection; however, other cofactors such as endogenous hormones could contribute to the development of this neoplasia. This work aims to determine the relationship between serum concentrations of sex steroid hormones, cortisol, prolactin, and insulin and the degree of cervical squamous intraepithelial lesions in Cuban women. A descriptive and cross-sectional study was carried out at the National Institute of Oncology and Radiobiology. It included 205 women who attended a Gynecology consultation for a cytological diagnosis confirmation of SIL during 2018-2020. Blood samples were collected to determine serum concentrations of estradiol, testosterone, prolactin, cortisol, and insulin. A questionnaire about socio-demographic variables, toxic habits, and gynecological and obstetric history of the patients was applied. Were found high-grade SILs mainly in women between 36 and 45-years-old and those who had one or two births. Serum concentrations of testosterone and insulin were the only ones that showed significant differences between women who presented SIL concerning negative cytology. A 3,23-fold (CI 95% 1.55-6.73) risk of developing SIL was found when testosterone concentrations were superior to 2 nmol/L and a 2,63-fold (CI 95% 1.36-5.09) risk when the insulin concentration was greater than 12 μU/mL. The association of elevated serum concentrations of testosterone and insulin with the presence of SIL may be related to increased bioavailability of estrogens, which may cooperate with viral oncogenes in cervical carcinogenesis. Additionally, mitogenic activity of insulin and its influence on increased IGF-1 bioactivity may facilitate malignant transformation and viral survival. New research is required to determine the mechanisms involved in this process and elucidate whether there is a cooperation between both hormones during the progression to CxCa.

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Section: Discussionmentioning

confidence: 70%

Association of Serum Concentrations of Testosterone and Insulin with the Degree of Cervical Squamous Intraepithelial Lesions in Cuban Women

Maydelin¹,

Eduardo²,

Cabrera³

et al. 2022

J Cervical Cancer Res

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Section: Discussionmentioning

confidence: 74%

“…Another study supports that high IGF-1 and IGF-2 levels were associated with an increased risk of squamous intraepithelial lesions of the cervix 36 . Additionally, high IGF-1 levels and elevated IGF-1: IGFBP-3 (insulin-like growth factor binding protein-3) ratios among premenopausal and postmenopausal women have been associated with higher terminal duct lobular unit counts, which are related to increased risk of breast cancer 37 .…”

Section: Discussionmentioning

confidence: 74%

Effects of Moxibustion on the Levels of Insulin-Like Growth Factor 1

Lin

et al. 2018

Cell Transplant

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Moxibustion (艾灸) is a traditional Chinese medicine therapy performed using Artemisia argyii. Zusanli (足三里, ST36) is an acupoint in the stomach meridian, long associated in ancient Chinese medical practices with the extension of life span when moxibustion is applied to it. The aim of this study was to investigate changes in insulin-like growth factor 1 (IGF-1) levels after application of moxibustion to ST36. Four healthy men and women participated in this 28-day trial and were randomly divided into 2 groups. Group A received moxibustion treatment from days 1 to 14, while group B received moxibustion treatment from days 15 to 28. Blood samples were taken 5 times during this study to measure serum IGF-1 (s-IGF-1) levels. The s-IGF-1 levels increased in both groups after 7 and 14 d of moxibustion therapy (group A: 11.02% [7 d] and 29.65% [14 d]; group B: 169.12% [7 d] and 274.85% [14 d]). After moxibustion therapy had been completed (day 14), s-IGF-1 levels continued to increase in group A (increases on day 21 and day 28 were 53.19% and 61.45%, respectively). There were no adverse events in either group. The s-IGF-1 levels were significantly raised in both groups after 7 and 14 d of moxibustion therapy. Moreover, once therapy had been completed, s-IGF-1 levels continued to increase in group A up to 14 d after the treatment.

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“…High concentrations of insulin can reduce the formation of insulin-like growth factor binding protein-1 and develop the synthesis of insulin-like growth factor 1 (IGF-1), which can in turn increase the risk of cancers by inducing cell proliferation and differentiation, and inhibiting apoptosis and synthesis of sex steroids [20]. Several studies have reported that a high intake of carbohydrates results in elevated IGF levels, which may strengthen the emergence of cervical carcinogenesis, but others showed inconsistent and mixed findings [21][22][23][24][25]. IGF stimulates the mitogenic effect of epidermal growth factor on HT-3 cervical cancer cells, increasing cell proliferation [21].…”

Section: Introductionmentioning

confidence: 99%

Associations of Dietary Glycemic Index, Glycemic Load and Carbohydrate with the Risk of Cervical Intraepithelial Neoplasia and Cervical Cancer: A Case-Control Study

2020

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Background: The association of dietary glycemic index (GI) and glycemic load (GL) with the risk of cervical cancer has never been investigated. Thus, we aimed to find evidence of any association of GI and GL with the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: In this hospital-based case-control study, we included 1340 women (670 controls and 262, 187 and 221 patients with CIN1, CIN2/3, and cervical cancer, respectively) from the Korean human papillomavirus cohort study. Completed demographic questionnaires and semi-quantitative food-frequency questionnaires were collected. The association of dietary GI and GL with CIN and cervical cancer was estimated using a logistic regression model. Results: The multivariate odds ratios (OR) of the highest compared with the lowest quintile of GL for CIN1 were 2.8 (95% confidence interval (CI) = 1.33–5.88). Dietary GI and GL were not associated with CIN2/3 and cervical cancer. Stratified analyses by body mass index (BMI) indicated a positive association between GI and GL and CIN 1 risk among women with a BMI (in kg/m2) <23 (OR = 2.94; 95% CI = 1.32–6.53; p for trend = 0.031 for GI and OR = 3.15; 95% CI = 1.53–6.52; p for trend = 0.013 for GL), but not among those with a BMI of ≥23. A stratification analysis by menopausal status showed that the highest quintile of GI and GL was significantly associated with the risk of CIN1 (OR = 2.91; 95% CI = 1.43–5.96; p for trend = 0.005) (OR = 2.96; 95% CI = 1.53–5.69; p for trend = 0.023) among premenopausal women. Also, in HPV positive women, dietary GL showed significant CIN1 risk (OR = 2.61; 95% CI = 1.09–6.24; p for trend = 0.087). Conclusion: Our case-control study supports the hypothesized associations of dietary GI and GL with increased risk of CIN1. Thus, the consumption of low GI and GL foods plays a significant role in the prevention of cervical carcinogenesis.

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Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix

Abstract: Elevated levels of IGF-I and IGF-II are associated with risk of SIL while BEMR emerges out to be a derived factor strongly associated with risk of SIL.

Cited by 3 publications

References 31 publications

Association of Serum Concentrations of Testosterone and Insulin with the Degree of Cervical Squamous Intraepithelial Lesions in Cuban Women

Association of Serum Concentrations of Testosterone and Insulin with the Degree of Cervical Squamous Intraepithelial Lesions in Cuban Women

Effects of Moxibustion on the Levels of Insulin-Like Growth Factor 1

Associations of Dietary Glycemic Index, Glycemic Load and Carbohydrate with the Risk of Cervical Intraepithelial Neoplasia and Cervical Cancer: A Case-Control Study

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