Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

Abstract

Background: Although Asians are generally characterized by lower body mass index (BMI) compared to Caucasians, the prevalence of gestational diabetes mellitus (GDM) among Asian women is higher. Our previous studies found that, like the Caucasians, pregnant Chinese women show difference between GDM and non-GDM in the levels of total adiponectin. However, there is no difference in other inflammatory markers such as CRP, TNFα, IL-6 or MCP-1. The aim of the present study was to assess the IGF-I, IGFBP-1, and FGF21 levels in Chinese-American women with and without GDM.