Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies

Piau, Tathyana Benetis; de Queiroz Rodrigues, Aline; Paulini, Fernanda

doi:10.1016/j.ghir.2023.101561

Cited by 3 publications

(1 citation statement)

References 202 publications

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“…Therefore, growth factors such as insulin-like growth factors (IGF1 and IGF2), which are produced by endometrial tissue, may play a role in inducing cell proliferation and differentiation [4]. The highest levels of IGF1 and IGF2 expression occur in the late and early proliferative phases, respectively [5]. Angiogenesis is an important process in the development of endometrial tissue, regulated by vascular endothelial growth factor (VEGF) [6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Smolarz,

Szaflik,

Romanowicz

et al. 2024

IJMS

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The coordinated action of VEGF, IGF1/2 and H19 factors influences the development of endometriosis. The aim of this study was to analyze the expression level of these genes in patients with endometriosis. The study group consisted of 100 patients who were diagnosed with endometriosis on laparoscopic and pathological examination. The control group consisted of 100 patients who were found to be free of endometriosis during the surgical procedure and whose eutopic endometrium wasnormal on histopathological examination. These patients were operated on for uterine fibroids. Gene expression was determined by RT-PCR. The expression of the VEGF gene was significantly higher in the samples classified as clinical stage 1–2 compared to the control material (p < 0.05). There was also a statistically significant difference between the samples studied at clinical stages 1–2 and 3–4 (p < 0.01). The expression of the VEGF gene in the group classified as 1–2 was significantly higher. IGF1 gene expression was significantly lower both in the group of samples classified as clinical stages 1–2 and 3–4 compared to the control group (p < 0.05 in both cases). The expression of the H19 gene was significantly lower in the group of samples classified as clinical stage 3–4 compared to the control group (p < 0.01). The reported studies suggest significant roles of VEGF, IGF and H19 expression in the pathogenesis of endometriosis.

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Section: Introductionmentioning

confidence: 99%

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Smolarz,

Szaflik,

Romanowicz

et al. 2024

IJMS

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Effects of in vivo Administration of Insulin-Like Growth Factor-1 on Oocyte and Embryo Development in Mice under Chronic Psychosocial Stress

Igonina,

Lebedeva,

Shavshaeva

et al. 2024

J Evol Biochem Phys

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Proteomic Analysis of Follicular Fluid in Polycystic Ovary Syndrome: Insights into Protein Composition and Metabolic Pathway Alterations

Przewocki,

Łukaszuk,

Jakiel

et al. 2024

IJMS

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This study explores the proteomic composition of follicular fluid (FF) from women undergoing oocyte retrieval for in vitro fertilisation (IVF), with a focus on the effects of polycystic ovary syndrome (PCOS). FF samples were collected from 74 patients, including 34 with PCOS and 40 oocyte donors. Proteomic profiling using machine learning identified significant differences in protein abundance between the PCOS and control groups. Of the 484 quantified proteins, 20 showed significantly altered levels in the PCOS group. Functional annotation and pathway enrichment analysis pointed to the involvement of protease inhibitors and immune-related proteins in the pathophysiology of PCOS, suggesting that inflammation and immune dysregulation may play a key role. Additionally, HDL assembly was identified as a significant pathway, with apolipoprotein-AI (APOA1) and alpha-2-macroglobulin (A2M) as the major proteins involved. Notably, myosin light polypeptide 6 was the most downregulated protein, showing the highest absolute fold change, and may serve as a novel independent biomarker for PCOS.

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Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies

Cited by 3 publications

References 202 publications

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Effects of in vivo Administration of Insulin-Like Growth Factor-1 on Oocyte and Embryo Development in Mice under Chronic Psychosocial Stress

Proteomic Analysis of Follicular Fluid in Polycystic Ovary Syndrome: Insights into Protein Composition and Metabolic Pathway Alterations

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