“…Mutations associated with NIDDM have been identified in the insulin [2], insulin receptor [3,4], glucokinase [5][6][7] and mitochondrial genes [8,9]. This suggests that direct screening of other candidate Received: 6 June 1994 and in revised form: 15 August 1994 Corresponding author: Dr. H. Makino, Second Department of Internal Medicine, Chiba University School of Medicine, 1-8-1 Inohana Chuo-ku, Chiba 260, Japan Abbreviations: NIDDM, Non-insulin-dependent diabetes mellitus; GLUT2, glucose transporter 2; IRS1, insulin receptor substrate-1; SSCR single-stranded conformation polymorphism; PCR, polymerase chain reaction; Thr, threonine; Phe, phenylalanine; Ala, alanine; Ser, serine; Ile, isoleucine; Val, valine; Gly, glycine.…”