2011
DOI: 10.1001/archneurol.2010.225
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Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

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Cited by 548 publications
(495 citation statements)
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“…113 This stands in contrast both to the recently reported findings of cardiovascular risk-related prefrontal hypofunctioning in elderly subjects classified using the FCHDR index 166 and to the results of other FDG-PET imaging studies that investigated the influence of single CVRFs on brain functioning. [95][96][97][98] One important difference between our PET study and the one by Kuczynski et al 166 is that the authors of the latter study did not exclude subjects with lacunar infarcts. They Figure 2 Reduced brain glucose metabolism in older adults with high cardiovascular risk.…”
Section: The Effects Of Combined Cvrfsmentioning
confidence: 79%
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“…113 This stands in contrast both to the recently reported findings of cardiovascular risk-related prefrontal hypofunctioning in elderly subjects classified using the FCHDR index 166 and to the results of other FDG-PET imaging studies that investigated the influence of single CVRFs on brain functioning. [95][96][97][98] One important difference between our PET study and the one by Kuczynski et al 166 is that the authors of the latter study did not exclude subjects with lacunar infarcts. They Figure 2 Reduced brain glucose metabolism in older adults with high cardiovascular risk.…”
Section: The Effects Of Combined Cvrfsmentioning
confidence: 79%
“…Moreover, insulin resistance correlated negatively with the connectivity between the posterior cingulate cortex and the right inferior frontal gyrus and the right precuneus. 135 It is interesting to note the existing overlap between these results and the regions presenting negative correlations between resting CMRgl and insulin resistance as found by another group 97 ; one possibility is that insulin resistance impairs neural metabolism, thus leading to less efficient interregional network integration and to a number of pathophysiological processes related to AD. 136,137 Hippocampal connectivity has been studied in older adults with type 2 diabetes using rs-fMRI.…”
Section: Cardiovascular Risk Factors and Cognitive Declinementioning
confidence: 82%
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