Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner

Abstract

Sevoflurane anesthesia impairs glucose tolerance to the same degree as does isoflurane anesthesia. Glucose intolerance during sevoflurane or isoflurane anesthesia is independent of agent and dosage up to 1.5 MAC.

Valuation of three different anaesthetic protocols on complete blood count and biochemical parameters on Wistar rats

“…Anaesthesia increases stress signals through catecholamines and cortisol excretion or may influence glucose homeostasis via insulin release. (Tanaka et al, 2005;Zuurbier et al, 2008). Studies on mice and rats have confirmed that a decrease in body temperature, as a result of anaesthesia, may further increase glucose levels (Tabata et al, 1998).…”

Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load

“…Volatile anesthetics, such as sevoflurane, attenuate insulin secretion by activating Table 6. Changes in blood glucose levels during insulin tolerance tests in groups S-ITT, SL-ITT, and P-ITT adenosine triphosphate-sensitive potassium channels in β-islet cells (2)(3)(4)(5). We previously found that propofol anesthesia enhances insulin secretion in rats (6,7).…”

“…Volatile anesthetics, such as sevoflurane, activate adenosine triphosphatesensitive potassium channels in β-islet cells, resulting in attenuated insulin secretion (2)(3)(4)(5). Although the precise mechanisms have not been elucidated, insulin secretion is significantly enhanced in rats under propofol anesthesia (6,7).…”

Hyperinsulinemic euglycemic step clamping with tracer glucose infusion and labeled glucose infusate for assessment of acute insulin resistance in pigs

“…Anesthesia in general alters glycemic homeostasis, and inhalation anesthetics in particular are known to diminish glucose-stimulated insulin secretion (24). If combined with invasive experimental techniques, these basal premises for utilization of step hot-GINF HEC might additionally be altered by elevated counterregulatory hormones due to surgical instrumentation.…”