Intact Transition Epitope Mapping—Force Interferences by Variable Extensions (ITEM-FIVE)
Cornelia Koy,
Claudia Röwer,
Hans-Jürgen Thiesen
et al.
Abstract:Investigations on binding strength differences of non-covalent protein complex components were performed by mass spectrometry. T4 fibritin foldon (T4Ff) is a well-studied miniprotein, which together with its biotinylated version served as model system to represent a compactly folded protein to which an Intrinsically Disordered Region (IDR) was attached. The apparent enthalpies of the gas phase dissociation reactions of the homo-trimeric foldon F-F-F and of the homo-trimeric triply biotinylated foldon bF-bF-bF … Show more
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