Integra artificial skin® in use for full-thickness burn surgery: Benefits or harms on patient outcome

The use of dermal substitutes in burn surgery: Acute phase

“…43 Its design also allows for ease of use given its immediate availability and shelf storage. 43 Despite the benefits of this dermal substitute and its use worldwide, there is still paucity of scientific evidence for its use. 37,43 The main complication appears to be a collection of hematomas and seromas beneath the product, which increases its susceptibility to infection; 35,37 however, this can be prevented by careful surgical technique.…”

“…43 Despite the benefits of this dermal substitute and its use worldwide, there is still paucity of scientific evidence for its use. 37,43 The main complication appears to be a collection of hematomas and seromas beneath the product, which increases its susceptibility to infection; 35,37 however, this can be prevented by careful surgical technique. 39 As this dermal substitute has no intrinsic antibacterial qualities, careful wound preparation with an antiseptic wash and meticulous hemostasis is essential.…”

“…Social, cultural, and ethical problems may arise as well because of animal tissue components. 43 Furthermore, this dermal substitute must be avoided in patients that have developed allergic reactions to bovine products. 36 The inability to replace the dermal and epidermal layer simultaneously because of the lack of real and permanent epidermal components 25 is the main disadvantage of this popular dermal substitute.…”

Bioengineered Skin for Aesthetic Reconstruction of the Tip of the Nose: A Case Report

“…As healing progresses collagen is deposited by the host fibroblasts, which replaces the bovine collagen and chondroitin 6‐sulfate while the silicone layer provides adequate moisture control. Subsequently the silicone layer is removed and an epidermal autograft is placed over the neodermis to reconstitute a functional dermis and epidermis 6–8 . Histologic structure, physical properties, and clinical features of induced neodermis closely resemble those of normal skin 9–11 .…”

Bacterial nanocelullose in biomedical applications: a review

“…They are also used as models for experimental tests. [14][15][16][17][18][19] The huge demand for the production of artificial skin, which will largely resemble human skin, has resulted in many studies with interesting results. 20 Currently many skin substitutes are used clinically.…”