Integra ® as a single-stage dermal regeneration template in reconstruction of large defects of the scalp

Vithlani, Gauri; Jorge, Paredes-Mendoza; Brizman, Eitan; Mitsimponas, Konstantinos

doi:10.1016/j.bjoms.2017.08.006

Cited by 13 publications

(13 citation statements)

References 6 publications

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“…All the 17 selected studies (Table 1 ) involved a retrospective analysis: 10 were case series 12 – 21 and 7 were case reports. 22 – 28 In particular, among case series, only patients who met the inclusion criteria were considered and included in our review.…”

Section: Resultsmentioning

confidence: 99%

“…Scalp reconstruction after melanoma excision deserves further important considerations. In our review, the age of patients ranged from 24 13 to 87 22 years, which leads us to consider several variables: for example, the importance of obtaining an aesthetically acceptable result and the complexity of the surgical procedure that the patients can handle. Young patients generally demand reconstructions that provide for the presence of hair and that can quickly help them recover a normal social life.…”

Section: Discussionmentioning

confidence: 99%

“… 42 Moreover, many of the articles selected for this review confirmed the effectiveness of this method to convert an exposed skull bone defect into a wound that can be skin grafted. 14 , 15 , 19 , 21 , 22 Doubtless, when full-thickness calvarial resection (that results in dural exposure) is included in the WLE, coverage with well-vascularized tissue is required. 29 Although free flaps are able to provide a solid and long-lasting reconstruction, they have some limitations.…”

Section: Discussionmentioning

confidence: 99%

“…The reconstruction methods described in the selected articles ranged from skin grafting, whether 14 , 15 , 19 , 21 , 22 or not 20 preceded by a bovine collagen construct, to local flaps (associated 26 – 28 or not 16 , 24 , 25 with skin grafting), local pedicle flaps (with skin graft of the donor area), 12 and free flaps. 13 , 17 , 18 , 23 In 1 patient, the one with the largest defect described, bilateral free ALT flaps were harvested.…”

Section: Reconstruction Strategiesmentioning

confidence: 99%

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Surgical Reconstruction following Wide Local Excision of Malignant Melanoma of the Scalp

Baldelli

Mangialardi

Salgarello

et al. 2020

Plastic and Reconstructive Surgery - Global Open

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Background: Scalp reconstruction in cases of melanoma excision can be challenging due to specific functional and aesthetic outcome requirements. Reconstructive techniques reported in the literature were reviewed to establish whether a surgical algorithm for the management of melanoma of the scalp may be deduced. Methods: A literature search was conducted to evaluate reconstructive strategies after melanoma wide local excision of the scalp according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Inclusion criteria were English language, diagnosis of melanoma of the scalp, and the presence of the following data: characteristics of the residual defect (width and depth), type of reconstruction, follow-up, and surgical outcome. Results: Six hundred twenty-five records were identified after excluding the duplicates; 48 full-text articles were assessed for eligibility, and 17 records were selected for inclusion. A total of 39 patients were included in the review. The majority of patients (n = 20) underwent skin grafting subsequent to dermal regeneration template positioning. Local flaps (n = 10), free flaps (n = 7), skin grafting alone (n = 1), and dermal regeneration template positioning alone (n = 1) were less frequent. Conclusions: Numerous reconstructive strategies for the scalp are described in the literature. Melanoma patients present a greater variability in terms of general health conditions and social needs that must be taken into account while choosing the most suitable procedure.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Reconstruction Strategiesmentioning

confidence: 99%

See 2 more Smart Citations

Surgical Reconstruction following Wide Local Excision of Malignant Melanoma of the Scalp

Baldelli

Mangialardi

Salgarello

et al. 2020

Plastic and Reconstructive Surgery - Global Open

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“…Despite all these significant advancements in the field, clinical data have yielded contradictory outcomes for collagen-based devices. For example, both tissue grafts [26][27][28][29][30][31] and extracted collagen devices [32][33][34][35][36][37][38][39][40] have shown both positive and negative clinical outcomes, suggesting that other factors than the extraction or crosslinking methods are at play. In this context, previous studies suggest that collagen retains the memory of the tissue that it derives from, affecting the physicochemical and biological properties of the final product/device.…”

Section: Introductionmentioning

confidence: 99%

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

Sorushanova

Tsiapalis

Skoufos

et al. 2022

MedComm – Biomaterials and Applications

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Recent data suggest that collagen retains the memory of the tissue that it derives from. With this in mind, collagen (from bovine skin and tendon) sponges were fabricated with different crosslinking densities, and their physicochemical and biological properties were assessed. As the crosslinking density was increased, the resistance to collagenase digestion, denaturation temperature, compressive stress, and compressive modulus was significantly increased and the free amine content, % swelling, and human dermal fibroblast cytocompatibility were significantly reduced. The tendon‐collagen‐derived scaffolds exhibited significantly higher compressive stress and compressive modulus values and induced significantly higher human tenocyte DNA concentration and metabolic activity than the skin‐collagen‐derived scaffolds. In human tenocyte cultures on day 14, the 1 mM 4‐arm polyethylene‐glycol succinimidyl glutarate tendon‐collagen‐derived collagen sponges induced significantly higher collagen type III synthesis (as expected at early stages of physiological tendon healing) and downregulated actin alpha 2 (associated with myofibroblast differentiation) and the skin‐collagen‐derived collagen sponges induced significantly higher collagen type IV synthesis (found primarily at the dermal‐epidermal junction) and upregulated prolyl 4‐hydroxylase subunit alpha‐1 (associated with collagen biosynthesis and constitutes a target for antifibrotic compounds). Our data indicate that the tissue from which collagen is extracted should be considered in the development of medical devices.

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Novel Use of a Biologically Active-Prefabricated-Random-Three-Dimensional-Polymer Scaffold of Hyaluronic Acid (HYAFF) to Facilitate Complicated Wound Closure

Luttrell

Rosenberry

Estacado

et al. 2018

Burns, Infections and Wound Management

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Integra ® as a single-stage dermal regeneration template in reconstruction of large defects of the scalp

Cited by 13 publications

References 6 publications

Surgical Reconstruction following Wide Local Excision of Malignant Melanoma of the Scalp

Surgical Reconstruction following Wide Local Excision of Malignant Melanoma of the Scalp

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

Novel Use of a Biologically Active-Prefabricated-Random-Three-Dimensional-Polymer Scaffold of Hyaluronic Acid (HYAFF) to Facilitate Complicated Wound Closure

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