Integracide K: A New Tetracyclic Triterpenoid fromDesmodium uncinatum(Jacq.) DC. (Fabaceae)

Abstract

− A new tetracyclic triterpenoid [4,4,24-trimethylcholesta-Δ 8,9;14,15;24,28 -trien-3β,11β,12α-triol-12-acetate, 3-sulfate] sodium salt (1), together with eight known compounds including ergosterol 5α,8α-endoperoxide (2), 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (3), 3-O-β-D-2-acetyl-amino-2-deoxyglucopyranoxyloleanoic acid (4), hydnocarpin (5), derrone (6), isovitexin (7), erythrinin C (8), and 5,4'-dihydroxy-2''-hydroxyisopropyldihydrofurano [4,5:7,8]-isoflavone (9), were isolated from the EtOAc soluble fraction of the methanol extract of aerial part of Desmodium uncinatum collected in the western highland of Cameroon. The structures of these compounds were established by comprehensive interpretation of their spectral data mainly including 1D-(

Cytotoxicity, Antioxidant Activities, GC-MS and HPLC Fingerprint Analyses of Different Extracts of Desmodium tortuosum (Sw.) DC

“…(III) &] of D. tortuosum leaves were subjected to chemical profiling through the HPLC-fingerprint technique to identify their chemical ingredients and to characterize the available classes of secondary metabolites [43]. In this study, fourteen standard phenolics were used as reference compounds, including gallic acid (1), chlorogenic acid (2), catechin (3), caffeic acid (4), syringic acid ( 5), rutin (6), ellagic acid (7), coumaric acid (8), vanillin (9), ferulic acid (10), naringenin (11), propyl gallate (12), quercetin (13), and cinnamic acid (14). The obtained results revealed the variable amounts of the above-mentioned standard compounds in the tested samples.…”

“…Most of its plants are herbs, shrubs, or sub-shrubs, but rarely trees. Besides their popularity as feeding stuffs, they are also used in traditional medicine [9]. Desmodium styracifolium (Osbeck) Merr.…”

Protective Effects of Extracts, Isolated Compounds from <i>Desmodium uncinatum</i> and Semi-Synthetic Isovitexin Derivatives against Lipid Peroxidation of Hepatocyte’s Membranes

“…Its cylindrical or angular stems are covered with short, hooked hairs that stick to hair or clothing [15]. Previous phytochemical investigations of this plant revealed the presence of flavonoids as uncinanone A, B, C, D and E, uncinacarpan and triterpenoids [16] [17] [18]. Based on the potent hepatoprotective effects of plants from the same genus, we hypothesized that the entire aerial part of D. uncinatum may possess bioactive compounds with hepatoprotective activities resulting from their ability to inhibit lipid peroxidation.…”