2017
DOI: 10.1101/226449
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Integrated Analysis of Gene Expression Differences in Twins Discordant for Disease and Binary Phenotypes

Abstract: While both genes and environment contribute to phenotype, deciphering environmental contributions to phenotype is a challenge. Furthermore, elucidating how different phenotypes may share similar environmental etiologies also is challenging. One way to identify environmental influences is through a discordant monozygotic (MZ) twin study design. Here, we assessed differential gene expression in MZ discordant twin pairs (affected vs. non-affected) for seven phenotypes, including chronic fatigue syndrome, obesity,… Show more

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