2023
DOI: 10.3390/microbiolres14030097
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Integrated Analysis of Long Non-Coding RNA Expression Profiles in Glaesserella parasuis-Induced Meningitis: New Insight into Pathogenesis

Peiyan Sun,
Yaqiong Yang,
Hongxing Cheng
et al.

Abstract: Glaesserella parasuis (G. parasuis) can elicit meningitis in pigs; however, the pathogenic mechanisms of meningitis induced by G. parasuis remain unclear. Long non-coding RNAs (lncRNAs) have been proven to play key roles in a variety of physiological and pathological processes. However, whether lncRNAs are involved in meningitis triggered by G. parasuis has not been investigated. In this study, we performed an integrative analysis of lncRNAs expression profiles in the porcine brain infected with G. parasuis us… Show more

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Cited by 4 publications
(4 citation statements)
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“…In the analysis using the STRING Database, the organism was set as Homo sapiens (human), and to ensure strong interactions a high confidence score threshold of 0.9 was applied for this analysis. The resulting analysis data are presented in TSV format from the STRING database and downloaded to be processed for advanced analysis using CytoScape Version 3.10.1 for in-depth investigation of network analysis which also allows exploration of key network parameters such as degree, betweenness centrality, and closeness centrality between receptors [ 32 ].…”
Section: Methodsmentioning
confidence: 99%
“…In the analysis using the STRING Database, the organism was set as Homo sapiens (human), and to ensure strong interactions a high confidence score threshold of 0.9 was applied for this analysis. The resulting analysis data are presented in TSV format from the STRING database and downloaded to be processed for advanced analysis using CytoScape Version 3.10.1 for in-depth investigation of network analysis which also allows exploration of key network parameters such as degree, betweenness centrality, and closeness centrality between receptors [ 32 ].…”
Section: Methodsmentioning
confidence: 99%
“…The final data were downloaded and displayed in TSV format. CytoScape 3.10.1 was then used for data processing for a thorough network analysis, study, and exploration of important network metrics, such as degree, betweenness centrality, and closeness centrality between signaling proteins [ 23 ].…”
Section: Methodsmentioning
confidence: 99%
“…After the analysis was completed, data were downloaded from the STRING database in TSV format. CytoScape Version 3.10.1 was then used to process the data for a more in-depth analysis, allowing for the exploration of important network parameters like degree, betweenness centrality, and closeness centrality between receptors [29].…”
Section: Network Pharmacology Analysismentioning
confidence: 99%
“…This poll indicates that obesity is no longer solely associated with wealth. In nations with a low socioeconomic index (SDI), the prevalence of obesity in young males (ages [25][26][27][28][29] has increased at the highest rate [5]. This result can be attributed to a combination of changes in diet, a sedentary lifestyle, the food environment, and social-cultural influences [6].…”
Section: Introductionmentioning
confidence: 99%