Integrated analysis of toxicity data of two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties to improve the understanding of side effects—A toxicopathologist׳s view

Kuper, C. Frieke; Vogels, Jack; Kemmerling, Jessica; Fehlert, Ellen; Rühl-Fehlert, Christine; Vohr, Hans-Werner; Krul, Cyrille

doi:10.1016/j.ejphar.2015.03.045

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…27 This discrepancy can be assumed to the varying exposure to HCB as well as the genetic differences across populations. 45 For peripheral vascular thrombosis and ischemia as vascular manifestations of SLE, serum concentrations of the detected OCs did not increase the risk of their occurrence. In harmony with the present finding, Min et al reported no association between serum levels of OC pesticides (p, p0-DDE, trans-nonachlor, oxychlordane, dieldrin, and β-HCH) and risk occurrence of peripheral vascular disease.…”

Section: Discussionmentioning

confidence: 86%

Association between toxic organochlorine levels in human serum and systemic lupus erythematosus

Helmy

Saad-Hussein

Rahman

et al. 2021

Lupus

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Organochlorines (OCs) are groups of highly toxic pesticides with known immunotoxicity. The present work aimed to study the potential association between serum residues of OCs and the risk of developing systemic lupus erythematosus (SLE) as well as correlating to the clinical-laboratory manifestations in a sample of Egyptian SLE patients. A cross-sectional study was conducted on 132 patients environmentally exposed to OCs. Patients were diagnosed as SLE based on the American College of Rheumatology (ACR) revised criteria. Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) score was calculated to stratify the disease severity. Blood and urine samples were collected to measure the levels of OCs, serological markers, and urinary protein. The most frequently detected OCs were p,p’-DDE; lindane; and hexachlorobenzene (HCB). The risk of developing SLE was significantly associated with detected p,p’-DDE and HCB (B value 7.704 and 14.33, respectively). Hexachlorobenzene, in addition, was significantly associated with increased SLEDAI-2K score and polycythemia. Lindane was significantly associated with hypocomplementemia, cardiac manifestations of SLE, anemia, and leucopenia. In conclusion, the detected OCs p,p’-DDE and HCB are associated with increased risk of SLE in Egyptian patients and correlates to the manifestations of disease severity.

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Section: Discussionmentioning

confidence: 86%

Association between toxic organochlorine levels in human serum and systemic lupus erythematosus

Helmy

Saad-Hussein

Rahman

et al. 2021

Lupus

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“…Due to the serious side-effects mentioned above, the usage of CAP has been totally banned in many countries [12,13]. However, it is still being used due to its high efficiency and low cost [14,15]. Thus, it is of great necessity and emergency to develop a highly sensitive, fast, and reliable analytical method for the trace-level detection of CAP in aquatic environments.…”

Section: Introductionmentioning

confidence: 99%

Intertwined Carbon Nanotubes and Ag Nanowires Constructed by Simple Solution Blending as Sensitive and Stable Chloramphenicol Sensors

Zhu

et al. 2021

Sensors

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Chloramphenicol (CAP) is a harmful compound associated with human hematopathy and neuritis, which was widely used as a broad-spectrum antibacterial agent in agriculture and aquaculture. Therefore, it is significant to detect CAP in aquatic environments. In this work, carbon nanotubes/silver nanowires (CNTs/AgNWs) composite electrodes were fabricated as the CAP sensor. Distinguished from in situ growing or chemical bonding noble metal nanomaterials on carbon, this CNTs/AgNWs composite was formed by simple solution blending. It was demonstrated that CNTs and AgNWs both contributed to the redox reaction of CAP in dynamics, and AgNWs was beneficial in thermodynamics as well. The proposed electrochemical sensor displayed a low detection limit of up to 0.08 μM and broad linear range of 0.1–100 μM for CAP. In addition, the CNTs/AgNWs electrodes exhibited good performance characteristics of repeatability and reproducibility, and proved suitable for CAP analysis in real water samples.

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Removal of pharmaceuticals by novel magnetic genipin-crosslinked chitosan/graphene oxide-SO3H composite

Liu

et al. 2019

Carbohydrate Polymers

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Integrated analysis of toxicity data of two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties to improve the understanding of side effects—A toxicopathologist׳s view

Cited by 5 publications

References 55 publications

Association between toxic organochlorine levels in human serum and systemic lupus erythematosus

Association between toxic organochlorine levels in human serum and systemic lupus erythematosus

Intertwined Carbon Nanotubes and Ag Nanowires Constructed by Simple Solution Blending as Sensitive and Stable Chloramphenicol Sensors

Removal of pharmaceuticals by novel magnetic genipin-crosslinked chitosan/graphene oxide-SO3H composite

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