Integrated approach in the assessment of skin compatibility of cosmetic formulations with green coffee oil

Wagemaker, Tais A. L.; Rijo, Patrícia; Rodrigues, Luís Monteiro; Campos, Patrícia Maria Berardo Gonçalves Maia; Fernandes, Ana Sofia; Rosado, Catarina

doi:10.1111/ics.12225

Cited by 33 publications

(25 citation statements)

References 19 publications

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“…9 More importantly, no skin erythema formation and inflammation was observed for this cream. Similarly, Wagemaker et al 39 conducted an animal experiment by irradiation of hairless mice smeared with green coffee oil cream and reported that the SPF of green coffee oil cream was proportional to the coffee oil content. Furthermore, the SPF of the cream (2.3) containing 15% green coffee oil was much higher than control (1.0).…”

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confidence: 99%

“…In another study, Wagemaker et al 5 further pointed out that the SPF of coffee oil extracted from C. arabica green coffee waste was about 1.5 as it could absorb UVB irradiation. In recent two studies, Wagemaker et al 9,39 prepared a cream composed of green coffee oil, cetearyl alcohol, ceteareth-20, glycerol, methyldibromo glutaronitrile, and butylated hydroxytoluene. Following the treatment of HaCaT cells with cream (10-100 µg/mL) for 24 h, the cell viability was .100%, implying that this cream did not show toxicity toward HaCaT cells.…”

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confidence: 99%

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Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth

Yang¹,

Hung²,

Chen³

2017

IJN

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Coffee grounds, a waste by-product generated after making coffee, contains approximately 15% coffee oil which can be used as a raw material in cosmetics. Algae oil rich in docosahexaenoic acid (DHA) has been demonstrated to possess anticancer and anti-inflammation functions. The objectives of this study were to develop a gas chromatography-mass spectrometry (GC-MS) method for the determination of fatty acids in coffee oil and algae oil and prepare a nanoemulsion for studying its inhibition effect on ultraviolet A-induced skin damage in mice and growth of melanoma cells B16-F10. A total of 8 and 5 fatty acids were separated and quantified in coffee oil and algae oil by GC-MS, respectively, with linoleic acid (39.8%) dominating in the former and DHA (33.9%) in the latter. A nanoemulsion with a particle size of 30 nm, zeta potential −72.72 mV, and DHA encapsulation efficiency 100% was prepared by using coffee oil, algae oil, surfactant (20% Span 80 and 80% Tween 80), and deionized water. Differential scanning calorimetry (DSC) analysis revealed a high stability of nanoemulsion when heated up to 110°C at a pH 6, whereas no significant changes in particle size distribution and pH occurred over a 90-day storage period at 4°C. Animal experiments showed that a dose of 0.1% coffee oil-algae oil nanoemulsion was effective in mitigating trans-epidermal water loss, skin erythema, melanin formation, and subcutaneous blood flow. Cytotoxicity test implied effective inhibition of melanoma cell growth by nanoemulsion with an IC 50 value of 26.5 µg/mL and the cell cycle arrested at G2/M phase. A dose-dependent upregulation of p53, p21, cyclin B, and cyclin A expressions and downregulation of CDK1 and CDK2 occurred. Also, both Bax and cytochrome c expressions were upregulated and bcl-2 expression downregulated, accompanied by a rise in caspase-3, caspase-8, and caspase-9 activities for apoptosis execution. Collectively, the apoptosis pathway of melanoma cells B16-F10 may involve both mitochondria and death receptor.

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Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth

Yang¹,

Hung²,

Chen³

2017

IJN

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“…The averaged values of three measurements were used for subsequent calculations (10) . Transepidermal Water Loss (TEWL) was measured with an evaporimeter (Tewameter ® TM 300, CK Eletronics GmbH, Koln, Germany), and registered in g/m 2 h (11) .…”

Section: Instrumentationmentioning

confidence: 99%

“…After two hours of study the stratum corneum water porímetro (Tewameter® TM 300, CK EletronicsGmbH, Koln, Alemanha) e registrado em g/m 2 h (11) . Os parâmetros do microrrelevo da pele foram avaliados usando o Visioscan ® VC98 e o software SELS 2000 da CK EletronicsGmbH (Koln, Alemanha).…”

Section: Effects After a Single Applicationunclassified

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Immediate and long term effects of a cosmetic formulation with Cichorium intybus root extract

Paseto¹,

Wagemaker²,

Campos³

2017

BBR

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220 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Immediate and long term effects of a cosmetic formulation with Cichorium intybus root extract AbstractDry skin is characterized as a rough and scaling skin surface. It usually has lower water content than normal skin. Vitamin D helps to regulate cellular proliferation and differentiation andcan help to protect skin from environmental factors. However, the stability vitamin D in cosmetic formulations is low. Thus, the aim of this study was to evaluate the sensory properties and protective effects on skin hydration of a cosmetic formulation containing Cichorium intybus root extract, previously shown to be "vitamin D like" (VD). A formulation containing VD or not (vehicle) was applied on the arm, forearm and face of fifteen subjects. Measurements of stratum corneum water content, Transepidermal Water Loss (TEWL) and skin microrelief parameters were performed using biophysical and skin image techniques before (baseline), after 2 hours, and after 45 and 90 days of daily application of the formulations. Only the formulation with VD was effective in maintaining skin barrier function and skin hydration under low humidity conditions. Cichorium intybus root extract is shown to be an effective "vitamin D like" active ingredient to use in cosmetic formulations to avoid skin dryness. In addition, the extract maintained the sensory properties of the studied cosmetic formulation.Keywords: Cichorium intybus root extract, "Vitamin D-like", cosmetics, biophysical techniques, skin dryness, sensory properties ResumoA pele seca é caracterizada como uma superfície áspera, com menor teor de água do que a pele normal. A Vitamina D ajuda a regular a proliferação e diferenciação celular e pode ajudar a proteger a pele contra fatores ambientais. No entanto, a Vitamina D é instável em formulações cosméticas. Assim, o objetivo deste estudo foi avaliar o sensorial e os efeitos protetores na hidratação da pele de uma formulação cosmética contendo extracto de raiz Cichorium intybus -"Vitamina D like" (VD). A formulação, adicionada ou não (veículo) de VD, foi aplicada no braço, antebraço e na face de quinze participantes. Antes (basal) e após 2 horas, 45 e 90 dias de aplicação diária das formulações foram realizadas medidas do conteúdo aquoso do estrato córneo, perda de água transepidémica e parâmetros do microrrelevo da pele por técnicas biofísicas e análise de imagem. Apenas a formulação com VD foi efetiva na manutenção da função barreira e hidratação da pele em condições de baixa umidade. Assim, oextracto de raíz de Cichorium intybus é um ingrediente ativo eficaz para aplicação em cosméticos para evitar o ressecamento da pele. Além disso, a "Vitamina D like" melhorou o sensorial da formulação cosmética estudada.Palavras chave: extracto de raiz de Cichorium intybus, "Vitamina D-like", cosméticos, técnicas de biofísica, pele seca, propriedades sensoriais.

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Multicomponent Petasis‐borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies

et al. 2016

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In this work we report the antibacterial activity of alkylaminophenols. A series of such compounds was prepared by a multicomponent Petasis-borono Mannich reaction starting from salicylaldehyde and its derivatives. The obtained compounds were tested against a large panel of microorganisms, Gram-positive and Gram-negative bacteria, and a yeast. Among the several tertiary amine derivatives tested, indoline-derived aminophenols containing a nitro group at the para-phenol position showed considerable activity against bacteria tested with minimal inhibitory concentrations as low as 1.36 μm against Staphyloccocus aureus and Mycobacterium smegmatis. Cytotoxicity of the new para-nitrophenol derivatives was observed only at concentrations much higher than those required for antibacterial activity.

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Integrated approach in the assessment of skin compatibility of cosmetic formulations with green coffee oil

Abstract: The results obtained in the study indicate that GCO seems to be safe for topical applications and showed good skin compatibility under the experimental conditions of the study.

Cited by 33 publications

References 19 publications

Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth

Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth

Immediate and long term effects of a cosmetic formulation with Cichorium intybus root extract

Multicomponent Petasis‐borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies

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