Integrated Approach to Study the Dehydration Kinetics of Nitrofurantoin Monohydrate

Investigation of Solid Phase Composition on Tablet Surfaces by Grazing Incidence X-ray Diffraction

“…Additionally, all solid forms were analyzed using thermal methods (DSC, TGA) and Raman and NIR spectroscopy. The results from these techniques were in accordance with the data reported in literature (25,34,(38)(39)(40). The phase identity of two forms, TP-DeH and NF-DeH, requires special mention here.…”

“…Though the conventional diffractogram of NF-DeH matched with the diffractogram of NF-β, peaks were broad and poorly resolved (data not shown). This indicates that the NF-DeH was a poorly crystalline material as reported earlier (39,45). Therefore, increase in the peak area due to the recrystallization of NF-DeH tablets should stem from the dehydration-induced as well as compactioninduced amorphization.…”

Nitrofurantoin– p ‐aminobenzoic acid cocrystal: Hydration stability and dissolution rate studies

“…The transformation of NF anhydrate to monohydrate was observed during dissolution,4,7 pelletization,12 and granulation 13. Dehydration kinetics of the monohydrate14 and solution behavior of NF anhydrate and monohydrate have been studied 15. Nitrofurantoin salts with sodium and potassium16 and l ‐arginine, l ‐lysine, l ‐histidine, l ‐ornithine, and glycine17 are known in the patent literature.The cocrystallization approach is attracting an immense interest from pharmaceutical scientists to control the physicochemical properties of drugs such as solubility, dissolution, hydration, stability, compaction, tableting, and so on 18–22.…”

Polymorphism and Solvatomorphism 2010

“…177 dehydration was not allowed by the positions of the water molecules in the crystal lattice. 150 The temperature dependence of the solubilities of naproxen sodium in methanol-water and ethanol-water solutions was used to map the solvatomorphs that could be crystallized under various conditions, as well as establishing the transition points at which the various solid-state forms could be in equilibrium. 151 The highly metastable form-III of paracetamol (acetaminophen) has been studied using rapid-heating DSC, where the form-III was first created in situ through appropriate solid-state transformations, thus creating the possibility for then studying the III → II transition.…”