Integrated community-based interventions for chronic obstructive pulmonary disease (COPD)：A systematic review and meta-analysis (Preprint)

Abstract

BACKGROUND Limited evidence supports integrated community-based interventions for chronic obstructive pulmonary disease (COPD) patients. We aimed to assess whether integrated community-based interventions could result in better health outcomes. OBJECTIVE We aimed to assess whether integrated community-based interventions could result in better health outcomes. METHODS Relevant articles published from January 1, 2005, to October 15, 2020 were obtained. A total of 28 reports with randomized controlled trials (RCTs) were finally included in this meta-analysis. RESULTS Integrated community-based interventions could reduce all-cause hospitalization days per patient [weighted mean difference (95% confidence interval) -1.50 (-2.39, -0.61)], improve 6-minutes walking distance [WMD (95% CI) 10.75 (10.64, 10.86)], and reduce St.George's Respiratory Questionnaire total score per year [WMD (95% CI) -3.36 (-5.30, -1.42)], while could not reduce yearly decline in the lung function, all-cause mortality and all-cause hospital admissions in COPD patients. The efficiency of integrated community-based interventions might attribute to the implements of physical activity, medication management, self-management and long-term intervention (i.e., >12 months). CONCLUSIONS Integrated community-based interventions may have a potential to improve health-related outcomes for COPD.