Data on the influence of abiotic and anthropogenic factors on the formation of crop productivity are important for the productive process management system. This work examines the results of a long-term study of the influence of abiotic (weather conditions) and anthropogenic (mineral fertilizers, an integrated plant protection system) factors on the formation of potato productivity in the North-West region of the Russian Federation. Weather conditions were the most significant (23.6%) among all the factors affecting the potato yield in the North-West region of the Russian Federation. Integrated plant protection and mineral nutrition had approximately equal contribution to the yield, i.e. 16.6% and 18.6% accordingly. In 2012–2020, additional potato yield reached 56–65% on average under the influence of mineral fertilizers, depending on their dose, and 37–56% under the influence of integrated plant protection Program. The combined influence of these two factors, taking into account the effect of interaction, led to an increase of the potato yield by 114-157% as compared with the actual yield on unfertilized and unprotected control (143 centners per hectare).