Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet

Shah, Manasvi S.; Schwartz, Scott; Zhao, Chen; Davidson, Laurie A.; Zhou, Beiyan; Lupton, Joannè R.; Ivanov, Ivan; Chapkin, Robert S.

doi:10.1152/physiolgenomics.00213.2010

Cited by 73 publications

(74 citation statements)

References 87 publications

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“…For instance, it was found that the anti-inflammatory effects of consuming a Mediterranean diet were related to hypermethylation of proinflammatory genes [84,85]. The administrations of polyunsaturated fatty acids positively modulated the expression of several miRNAs, which suppressed oncogenic and lipogenic genes [86,87]. Also, the anticancer properties of resveratrol, epigallocatechin-3-gallate, curcumin, sulforaphane, and genistein have been associated with some epigenetic modifications including hypomethylation and acetylation of tumor suppressor genes, and an increase in miRNAs targeting oncogenes (Table 6).…”

Section: Diet and Epigenetic Signaturesmentioning

confidence: 99%

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Ramos-López

Milagro

Allayee³

et al. 2017

Lifestyle Genomics

139

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Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual's genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses. This knowledge has led to the search for genetic and epigenetic biomarkers to predict the risk of developing chronic diseases and personalizing their prevention and treatment. Additionally, original nutritional interventions based on nutrients and bioactive dietary compounds that can modify epigenetic marks and gene expression have been implemented. Although caution must be exercised, these scientific insights are paving the way for the design of innovative strategies for the control of chronic diseases accompanying obesity. This document provides a number of examples of the huge potential of understanding nutrigenetic, nutrigenomic, and nutriepigenetic roles in precision nutrition.

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Section: Diet and Epigenetic Signaturesmentioning

confidence: 99%

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Ramos-López

Milagro

Allayee³

et al. 2017

Lifestyle Genomics

139

View full text Add to dashboard Cite

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“…The effects of dietary fish oil and pectin on miRNA expression during the early stages of colon tumorigenesis in preclinical models have been examined (46, 190). Table 1 summarizes specific miRNAs modulated by a combination fish oil and pectin diet with respect to their validated mRNA target genes.…”

Section: Effects Of N-3 Pufa Fiber and Curcumin On Noncoding Micrornasmentioning

confidence: 99%

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

et al. 2016

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The International Agency for Research on Cancer recently released an assessment classifying red and processed meat as “carcinogenic to humans” on the basis of the positive association between increased consumption and risk for colorectal cancer. Diet, however, can also decrease the risk for colorectal cancer and be used as a chemopreventive strategy. Bioactive dietary molecules, such as n-3 polyunsaturated fatty acids, curcumin, and fermentable fiber, have been proposed to exert chemoprotective effects, and their molecular mechanisms have been the focus of research in the dietary/chemoprevention field. Using these bioactives as examples, this review surveys the proposed mechanisms by which they exert their effects, from the nucleus to the cellular membrane. In addition, we discuss emerging technologies involving the culturing of colonic organoids to study the physiological effects of dietary bioactives. Finally, we address future challenges to the field regarding the identification of additional molecular mechanisms and other bioactive dietary molecules that can be utilized in our fight to reduce the incidence of colorectal cancer.

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“…Several studies have examined the effect of dietary components in other in vivo models. Examination of the miRNA response in rats fed diets containing corn or fish oil with pectin or cellulose and injected with a carcinogen or saline control particularly demonstrated a novel role for fish oil in protecting the colon from carcinogen-induced miRNA dysregulation, rather than a role for fiber (46,47). Shah and colleagues (47) did however demonstrate that various dietary combinations and carcinogen exposure modulated a number of miRNAs, including miR17-92 cluster miRNAs and miR21 (47).…”

Section: Cancer Prev Res; 7(8) August 2014mentioning

confidence: 99%

Dietary Manipulation of Oncogenic MicroRNA Expression in Human Rectal Mucosa: A Randomized Trial

Humphreys

Conlon

Young

et al. 2014

Cancer Prevention Research

100

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High red meat (HRM) intake is associated with increased colorectal cancer risk, while resistant starch is probably protective. Resistant starch fermentation produces butyrate, which can alter microRNA (miRNA) levels in colorectal cancer cells in vitro; effects of red meat and resistant starch on miRNA expression in vivo were unknown. This study examined whether a HRM diet altered miRNA expression in rectal mucosa tissue of healthy volunteers, and if supplementation with butyrylated resistant starch (HRMþHAMSB) modified this response. In a randomized cross-over design, 23 volunteers undertook four 4-week dietary interventions; an HRM diet (300 g/day lean red meat) and an HRMþHAMSB diet (HRM with 40 g/day butyrylated high amylose maize starch), preceded by an entry diet and separated by a washout. Fecal butyrate increased with the HRMþHAMSB diet. Levels of oncogenic mature miRNAs, including miR17-92 cluster miRNAs and miR21, increased in the rectal mucosa with the HRM diet, whereas the HRMþHAMSB diet restored miR17-92 miRNAs, but not miR21, to baseline levels. Elevated miR17-92 and miR21 in the HRM diet corresponded with increased cell proliferation, and a decrease in miR17-92 target gene transcript levels, including CDKN1A. The oncogenic miR17-92 cluster is differentially regulated by dietary factors that increase or decrease risk for colorectal cancer, and this may explain, at least in part, the respective risk profiles of HRM and resistant starch. These findings support increased resistant starch consumption as a means of reducing risk associated with an HRM diet. Cancer Prev Res; 7(8); 786-95. Ó2014 AACR.

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Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet

Abstract: JR, Ivanov I, Chapkin RS. Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemoprotective diet.

Cited by 73 publications

References 87 publications

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

Dietary Manipulation of Oncogenic MicroRNA Expression in Human Rectal Mucosa: A Randomized Trial

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