Integrated Nanoparticle–Biomolecule Hybrid Systems: Synthesis, Properties, and Applications

Abstract

Nanomaterials, such as metal or semiconductor nanoparticles and nanorods, exhibit similar dimensions to those of biomolecules, such as proteins (enzymes, antigens, antibodies) or DNA. The integration of nanoparticles, which exhibit unique electronic, photonic, and catalytic properties, with biomaterials, which display unique recognition, catalytic, and inhibition properties, yields novel hybrid nanobiomaterials of synergetic properties and functions. This review describes recent advances in the synthesis of biomolecule-nanoparticle/nanorod hybrid systems and the application of such assemblies in the generation of 2D and 3D ordered structures in solutions and on surfaces. Particular emphasis is directed to the use of biomolecule-nanoparticle (metallic or semiconductive) assemblies for bioanalytical applications and for the fabrication of bioelectronic devices.

Chromogenic and fluorogenic chemosensors and reagents for anions. A comprehensive review of the year 2009

“…145,146 Based in this phenomenon several sensing protocols have been described in recent years for both anion and cations and in the field of biomacromolecule analysis. 147,148 The AuNPs containing a novel p-sulfonatocalix [4]arene derivative attached to the gold surface via thiol groups (103, Figure 38) were used as colorimetric probe for the detection of A second example that uses selective aggregation of AuNPs is based on the Griess reaction for the selective detection of NO 2 -anion ( Figure 39). 150 Two types of AuNPs were prepared, AuNPs containing aniline groups (104) and AuNPs containing naphthalene moieties (105).…”

Comprehensive Screen of Metal Oxide Nanoparticles for DNA Adsorption, Fluorescence Quenching, and Anion Discrimination

“…[1][2][3][4][5][6] While DNA has been interfaced with metal and carbon-based nanomaterials, [6][7][8][9] limited work was carried out on metal oxide nanoparticles (MONPs). [10][11][12][13][14][15][16][17][18][19][20] MONPs represent a very important class of material due to their unique electronic, optical, magnetic and catalytic properties.…”

Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles

“…[4][5][6] Interfacing DNA with inorganic nanomaterials is a key step of bottom-up fabrication to produce functional hybrids and devices. [7][8][9] In particular, DNA-directed assembly of gold nanoparticles (AuNPs) has tremendously fueled the growth of nanobiotechnology. [10][11][12][13][14][15][16] The dense layer of DNA creates a unique colloidal system with many fundamentally interesting physical properties.…”