The genus Vaccinium, which includes approximately 450 species, features economically significant berries such as bilberries (Vaccinium myrtillus) and blueberries (Vaccinium corymbosum). Bilberries flourish in acidic, well-drained soils, typically found in heathlands and coniferous forests, while blueberries benefit from a broader range of soil types and intensive agricultural practices. Sustainable cultivation strategies, including organic fertilization and efficient water management, are vital for optimizing production and addressing the environmental challenges posed by climate change. Both berries are rich in antioxidants and other nutrients, driving consumer interest and market growth despite competition from alternative crops. Additionally, tailored fertilization techniques are crucial for maximizing yield and fruit quality. By implementing circular economy principles, the production of bilberries and blueberries can enhance sustainability and profitability, ensuring their long-term success in agricultural systems.