Integrated photonic glucose biosensor using a vertically coupled microring resonator in polymers

Kim, Gun-Duk; Son, Geun‐Sik; Lee, Hak‐Soon; Kim, Ki-Do; Lee, Sang‐Shin

doi:10.1016/j.optcom.2008.06.006

Cited by 50 publications

(37 citation statements)

References 13 publications

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“…These two approaches have been compared experimentally in several studies [52,53]. Spectral shift measurement is superior to intensity measurements in linear dynamic range and in system intensity noise resilience.…”

Section: Planar Microresonators and Microresonator Sensorsmentioning

confidence: 99%

Chip scale integrated microresonator sensing systems

Jokerst¹,

Royal

Palit

et al. 2009

Journal of Biophotonics

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Medicine, environmental monitoring, and security are application areas for miniaturized, portable sensing systems. The emerging integration of sensors with other components (electronic, photonic, fluidic) is moving sensing toward higher levels of portability through the realization of self-contained chip scale sensing systems. Planar optical sensors, and in particular, microresonator sensors, are attractive components for chip scale integrated sensing systems because they are small, have high sensitivity, can be surface customized, and can be integrated singly or in arrays in a planar format with other components using conventional semiconductor fabrication technologies. This paper will focus on the progress and prospects for the integration of microresonator sensors at the chip scale with photonic input/output components and with sample preparation microfluidics, toward self-contained, portable sensing systems.

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Section: Planar Microresonators and Microresonator Sensorsmentioning

confidence: 99%

Chip scale integrated microresonator sensing systems

Jokerst¹,

Royal

Palit

et al. 2009

Journal of Biophotonics

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“…That article also showed that adding size-selectivity negatively affects the precision of the measured RI change. However, using three wavelengths to discriminate between RI changes at three different layers within the evanescent field and assuming a phase precision of 10 −4 fringes and current waveguide specifications, the retained theoretical sensitivity is 1x10 −6 RIU corresponding to 0.8 pg/mm 2 , which is still comparable to the detection limits of other existing methods [16]. In the measurements shown in this contribution we discriminate between two substances of different sizes inducing a RI change by measuring the effective refractive index change eff N Δ at two wavelengths (457 and 660 nm).…”

Section: Young Interferometer With Multiple Wavelengthsmentioning

confidence: 99%

“…Examples of IO sensors are grating couplers [1], resonant optical microcavity sensors [2][3][4], photonic crystal waveguide sensors [5,6] and interferometric sensors [7][8][9][10][11]. Interferometric biosensors use the evanescent field to detect refractive index (RI) changes induced by analyte binding.…”

Section: Introductionmentioning

confidence: 99%

Size-selective analyte detection with a Young interferometer sensor using multiple wavelengths

Mulder¹,

Blum²,

Subramaniam³

et al. 2016

Opt. Express

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We present a method to discriminate between analytes based on their size using multiple wavelengths in a Young interferometer. We measured the response of two wavelengths when adding 85 nm beads (representing specific binding), protein A (representing non-specific binding) and D-glucose (inducing a bulk change) to our sensor. Next, the measurements are analysed using a approach based on theoretical analysis, and a ratio-based analysis approach to discriminate between bulk changes and the binding of the different sized substances. Moreover, we were able to discriminate binding of 85 nm beads from binding of protein A (~2 nm) in a blind experiment using the ratio-based approach. This can for example be used to discriminate specific analyte binding of larger particles from nonspecific binding of smaller particles. Therefore, we believe that by adding size-selectivity we can strongly improve the performance of the Young interferometer sensor and integrated optical interferometric sensors in general. 6396-6405 (2000). 8. C. Stamm, R. Dangel, and W. Lukosz, "Biosensing with the integrated-optical difference interferometer: dualwavelength operation," Opt. Commun. 153(4-6), 347-359 (1998). 9. K. Schmitt, B. Schirmer, C. Hoffmann, A. Brandenburg, and P. Meyrueis, "Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions," Biosens.

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“…Microring resonator based sensors are commonly used for different biological and chemical applications [86][87][88][89][90][91]. Combining this sensing technology with specifically synthesized receptors, the molecular identification of hazardous substances like nitroaromatic explosives becomes possible.…”

Section: Photonic Ring Resonator Sensorsmentioning

confidence: 99%

Detection of Explosives

Schade

Orghici

Mordmüller

et al. 2012

Handbook of Biophotonics

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Nowadays, much attention is given to the detection of explosives in order to prevent terrorist activities and assure security at airports, aviation, public transportation, convention halls, concerts, and so on. The location of undetonated and buried landmines is also a matter of great importance that could help to minimize fatalities and injuries among civilians caused by mines detonating. Another problem related to the use of explosives is the fact that nitrogen-based explosives, such as trinitrotoluene (TNT), are toxic and able to rapidly penetrate the skin, leading to significant health problems [1,2]. For this reason, the sensing of hazardous substances may be of great interest at many facilities, where explosive materials were/are still manufactured and deposited, in order to avoid contamination of the soil or groundwater with the toxic compounds that can result from improper waste disposal, and to ensure the safety of both workers and nearby residents.As can be seen, the detection of explosives is a significant task in the field of security and environmental analysis. Over the last several years major efforts have been focused on developing innovative sensing devices, capable of detecting hazardous species. In contrast to commonly used methods, such as ion mobility spectrometry (IMS), gas chromatography, or mass spectrometry, that require sampling for performing analysis and are relatively cost-intensive, optical methods are ideally suited for a fast online and in situ detection of hazardous substances due to their contact-free and nondestructive operation.However, at the present time, there is no sensing system available which can identify all explosive compounds, promising high sensitivity, selectivity, and low false-alarm rate, simultaneously. Depending on the nature of the applications, sensing devices based on different laser spectroscopic methods have been developed, each of them offering high efficiency for a specific type of explosive material. A reliable detection of explosive traces in the vapor phase or in the form of particles, essential for security applications, can only be achieved by combining the sensing methods and their respective features. In the following, an overview of several laser-

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Integrated photonic glucose biosensor using a vertically coupled microring resonator in polymers

Cited by 50 publications

References 13 publications

Chip scale integrated microresonator sensing systems

Chip scale integrated microresonator sensing systems

Size-selective analyte detection with a Young interferometer sensor using multiple wavelengths

Detection of Explosives

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